Genetic Variations in LDL Hyper-responders on Ketogenic Diet

This study is exploring why some individuals on a ketogenic diet, which is high in fats and low in carbohydrates, experience a significant increase in their LDL cholesterol levels. These individuals, known as "hyper-responders," might have specific genetic variations that affect how their bodies absorb cholesterol. The research focuses on identifying these genetic differences, which could help in understanding how diet and genetics interact, potentially leading to better dietary recommendations and treatments for managing cholesterol levels. Participants in the study will not take any medication or undergo treatments. Instead, the study observes their genetic makeup by analyzing specific genes related to cholesterol absorption, such as ABCG5, ABCG8, and others. Researchers will look for mutations in these genes to determine if they are linked to the increased LDL cholesterol levels seen in hyper-responders. The study's main goal is to count how many participants have these genetic mutations, providing insights into the genetic factors that might influence cholesterol levels on a ketogenic diet.