Carotid Doppler and Echocardiography in Paediatric Septic Shock
Data Collection
Collected from today forward - ProspectiveInfections+5
+ Inflammation
+ Pathologic Processes
Cohort
Tracking disease incidence in order to identify risk factors and understand disease progression over time.Summary
Study start date: September 1, 2025
Actual date on which the first participant was enrolled.This study focuses on improving the treatment for children experiencing septic shock, a serious condition where the body's response to infection can lead to dangerously low blood pressure and organ failure. The research aims to determine how well two tools, carotid Doppler ultrasound and echocardiography, can predict how these young patients will respond to fluid treatments. Understanding fluid responsiveness is crucial because it helps doctors decide how much fluid a child needs to stabilize their condition, potentially leading to better outcomes and less risk of complications. Participants in the study undergo various evaluations after receiving fluids to treat the septic shock. The assessments include a comprehensive clinical examination, which checks vital signs like blood pressure and heart rate, as well as urine output and other physical indicators. Blood tests are done to measure important markers such as kidney function and inflammation levels. Imaging techniques like echocardiography are used to gather detailed measurements of heart function and blood flow. These evaluations help determine the accuracy of the carotid Doppler and echocardiography in predicting how well children respond to fluid therapy, with the ultimate goal of enhancing treatment strategies for pediatric septic shock.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.50 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Cohort
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 1 Months to 16 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion criteria : * Children aged 1 month to 16 years. * Patients with septic shock admitted at the PICU during their fluid resuscitative phase were included.Septic shock was diagnosed according to phoenix sepsis score 2024 • Exclusion criteria: * Acquired and congenital heart disease. * Acquired and congenital renal disease. * Vascular anomalies (e.g. arteriovenous malformation, aneurysm). * Suspected intracranial hypertension. * Skin lesions or bandages at the sites of ultrasound or echo-cardiography examinations. * Anatomical anomalies of the neck.
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Ain shams university _faculty of medicine
Cairo, EgyptOpen Ain shams university _faculty of medicine in Google Maps