Recruiting

Carotid Doppler and Echocardiography in Paediatric Septic Shock

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Infections+5

+ Inflammation

+ Pathologic Processes

From 1 Months to 16 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: September 2025
See protocol details

Summary

Principal SponsorAin Shams University
Study ContactSara sobhy selim, assistant lecturer
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 1, 2025

Actual date on which the first participant was enrolled.

This study focuses on improving the treatment for children experiencing septic shock, a serious condition where the body's response to infection can lead to dangerously low blood pressure and organ failure. The research aims to determine how well two tools, carotid Doppler ultrasound and echocardiography, can predict how these young patients will respond to fluid treatments. Understanding fluid responsiveness is crucial because it helps doctors decide how much fluid a child needs to stabilize their condition, potentially leading to better outcomes and less risk of complications. Participants in the study undergo various evaluations after receiving fluids to treat the septic shock. The assessments include a comprehensive clinical examination, which checks vital signs like blood pressure and heart rate, as well as urine output and other physical indicators. Blood tests are done to measure important markers such as kidney function and inflammation levels. Imaging techniques like echocardiography are used to gather detailed measurements of heart function and blood flow. These evaluations help determine the accuracy of the carotid Doppler and echocardiography in predicting how well children respond to fluid therapy, with the ultimate goal of enhancing treatment strategies for pediatric septic shock.

Official TitlePrediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography
NCT07136532
Principal SponsorAin Shams University
Study ContactSara sobhy selim, assistant lecturer
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 1 Months to 16 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

InfectionsInflammationPathologic ProcessesShockShock, SepticPathological Conditions, Signs and SymptomsSystemic Inflammatory Response SyndromeSepsis

Criteria

Inclusion criteria : * Children aged 1 month to 16 years. * Patients with septic shock admitted at the PICU during their fluid resuscitative phase were included.Septic shock was diagnosed according to phoenix sepsis score 2024 • Exclusion criteria: * Acquired and congenital heart disease. * Acquired and congenital renal disease. * Vascular anomalies (e.g. arteriovenous malformation, aneurysm). * Suspected intracranial hypertension. * Skin lesions or bandages at the sites of ultrasound or echo-cardiography examinations. * Anatomical anomalies of the neck.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Ain shams university _faculty of medicine

Cairo, EgyptOpen Ain shams university _faculty of medicine in Google Maps
Recruiting
One Study Center