GAVEMicrovascular Abnormalities in GAVE Patients
Video Capillaroscopy
Cardiovascular Diseases+4
+ Digestive System Diseases
+ Gastrointestinal Diseases
Supportive Care Study
Summary
Study start date: May 3, 2025
Actual date on which the first participant was enrolled.This study focuses on understanding a condition called Gastric Antral Vascular Ectasia (GAVE), often referred to as "watermelon stomach," which can cause gastrointestinal bleeding. The researchers aim to find out how common certain abnormalities are in the tiny blood vessels near the nails, using a method called nail fold video capillaroscopy (NVC), in patients who have GAVE. This study is important because it may reveal patterns that can help doctors better understand and treat GAVE, potentially improving patient care. Participants in this study will undergo a nail fold video capillaroscopy, a non-invasive procedure that examines the small blood vessels at the base of the fingernails. They will also have an endoscopic examination of the stomach lining, called an EGD, to observe the GAVE. The study will compare findings from the NVC with how the patients present clinically, which means looking at their symptoms and other medical indicators. By doing this, the study aims to draw connections between these examinations and the patients' experiences.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.75 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Supportive Care Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 95 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Patients 18 years and older with gave diagnosis as pair EGD performed in Gastroenterology as standard of care. Patients with GAVE with connective tissue disease will be compared to patients with GAVE without a connective tissue disease. Exclusion Criteria: * Age less than 18 years of age, pregnant individuals, dialysis dependent, type 2 diabetes, recent hand trauma or manicure (\<2 weeks), routine use of vibratory tools, history of acrocyanosis or erythromelalgia, previous diagnosis of a bleeding disorder, diagnosis of psoriasis, diagnosis of anti-phospholipid syndrome, exposure to toluene or benzoyl, diagnosis of psoriasis, diagnosis of COPD.
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Group II
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 2 locations
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, United States