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Gastrointestinal Bleeding Risk in Ischemic Heart Disease on Antiplatelet Therapy

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What is being collected

Data Collection

Collected from past medical records and data - Retrospective
Who is being recruted

Arterial Occlusive Diseases+11

+ Arteriosclerosis

+ Cardiovascular Diseases

Over 18 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: September 2025
See protocol details

Summary

Principal SponsorAssiut University
Study ContactAbdulrahman Antar, Resident DoctorMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 1, 2025

Actual date on which the first participant was enrolled.

This clinical study focuses on patients with ischemic heart disease, a condition where blood flow to the heart is restricted due to narrowed or blocked arteries. The study aims to understand the frequency and risk of gastrointestinal bleeding, which is bleeding within the digestive system, in patients who are treated with either single or dual antiplatelet therapy. Antiplatelet medications like aspirin and clopidogrel are used to prevent blood clots and reduce heart attack risk, but they can also increase the chance of bleeding in the digestive tract. The study seeks to find ways to minimize these bleeding risks while maintaining the effectiveness of heart disease treatment. Participants in this study are observed to compare the rates of gastrointestinal bleeding between those on single antiplatelet therapy and those on dual therapy. The study is observational, meaning it does not involve any experimental treatment; instead, it monitors patients' health outcomes under their current medication regimens. Researchers measure the occurrence of bleeding events, looking at whether the use of one or two antiplatelet drugs affects the likelihood of bleeding complications. The ultimate goal is to identify safer treatment strategies for managing heart disease without increasing the risk of gastrointestinal issues.

Official TitlePrevalence of Gastrointestinal Bleeding in Ischemic Heart Disease Patients Undergoing Single Compared to Dual Antiplatelet Treatment
NCT07125651
Principal SponsorAssiut University
Study ContactAbdulrahman Antar, Resident DoctorMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

112 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Conditions

Pathology

Arterial Occlusive DiseasesArteriosclerosisCardiovascular DiseasesCoronary Artery DiseaseCoronary DiseaseDigestive System DiseasesGastrointestinal DiseasesHeart DiseasesHemorrhageGastrointestinal HemorrhagePathologic ProcessesPathological Conditions, Signs and SymptomsVascular DiseasesMyocardial Ischemia

Criteria

1 inclusion criteria required to participate
Patients (aged 18 years old and older) who were diagnosed ischemic heart disease on single or dual antiplatelet therapy and developed gastrointestinal bleeding (manifestation of hematemesis, melena or bleeding per rectum).

5 exclusion criteria prevent from participating
Patients on anticoagulant.

Patients with bleeding tendencies.

Individuals with other comorbidities.

patients with acute coronary syndrome.

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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