Completed

SMARCA4-Deficient Advanced Lung Cancer Characteristics and Treatment

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What is being collected

Data Collection

Collected from past medical records and data - Retrospective
Who is being recruted

Bronchial Neoplasms+7

+ Carcinoma, Bronchogenic

+ Carcinoma, Non-Small-Cell Lung

+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: January 2020
See protocol details

Summary

Principal SponsorShanghai Pulmonary Hospital, Shanghai, China
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2020

Actual date on which the first participant was enrolled.

This study aims to look into the traits and treatment outcomes related to a specific type of lung cancer, called SMARCA4-deficient advanced non-small-cell lung cancer (NSCLC). By examining existing medical records, the study seeks to better understand how this form of cancer behaves and how effective current treatments are. This information is particularly valuable for people with this rare type of lung cancer, as it might help improve future treatment options and patient care by providing insights into which therapies work best. Participants in this study do not receive any new treatment or intervention. Instead, researchers analyze past data from patients who have already been treated for their lung cancer. The main focus is on measuring how long patients live without their cancer getting worse, known as progression-free survival. This is done by looking at the time between the start of their first treatment and when their cancer first showed signs of progressing. The study's retrospective nature means it carries no additional risks to participants beyond those they faced during their initial treatment.

Official TitleA Real-World Retrospective Cohort Analysis of SMARCA4-Deficient Advanced Lung Cancer
NCT07121387
Principal SponsorShanghai Pulmonary Hospital, Shanghai, China
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

221 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Bronchial NeoplasmsCarcinoma, BronchogenicCarcinoma, Non-Small-Cell LungLung DiseasesLung NeoplasmsNeoplasmsNeoplasms by SiteRespiratory Tract DiseasesRespiratory Tract NeoplasmsThoracic Neoplasms

Criteria

3 inclusion criteria required to participate
Diagnosed with stage III-IV NSCLC according to the American Joint Committee on Cancer staging criteria (7th edition);
Lesions are measurable according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1;
Receiving first-line immunotherapy or chemotherapy as anti-tumor treatment.
3 exclusion criteria prevent from participating
SMARCA4 gene test was not performed;
Not receive treatment;
Lost to follow-up after one treatment cycle.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Shanghai Pulmonary Hospital

Shanghai, ChinaOpen Shanghai Pulmonary Hospital in Google Maps
CompletedOne Study Center