Recruiting

Listerine and Chlorhexidine Mouthwash for Orthodontic Patients

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What is being tested

Listerine Mouthwash Product

+ Chlorhexidine mouthwash

Drug
Who is being recruted

Dental Deposits+6

+ Dental Plaque

+ Gingival Diseases

From 13 to 40 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: August 2025
See protocol details

Summary

Principal SponsorKhyber Medical University Peshawar
Study ContactFazli Rabi, MPH*More contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2025

Actual date on which the first participant was enrolled.

Fixed braces used in orthodontic treatment can make it difficult to keep teeth clean, leading to plaque buildup and gum problems like gingivitis. While brushing and flossing help, they might not be enough, so mouthwashes can be a useful addition. This study focuses on comparing two types of mouthwash, Chlorhexidine (CHX) and Listerine, to see which one better improves gum health for people with braces. CHX is known for its strong effect against germs but can cause side effects like tooth staining and taste changes. Listerine, on the other hand, has fewer side effects and is easily available. This research could help find a more comfortable and effective mouthwash option for those with braces. In this study, 60 participants aged 13 to 25, undergoing orthodontic treatment, are divided into two groups to use either CHX or Listerine mouthwash for four weeks. The study is double-blind, meaning neither the participants nor the researchers know which mouthwash is being used to ensure unbiased results. Participants use the mouthwash provided in identical bottles, and their gum health is checked at the start, after two weeks, and at the end of the study. The main focus is on changes in plaque and gum health, checked by trained professionals. The study looks to see if Listerine can be as effective as CHX without the unwanted side effects, providing a safer option for those needing long-term use during their orthodontic treatment.

Official TitleComparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic Treatment
NCT07119840
Principal SponsorKhyber Medical University Peshawar
Study ContactFazli Rabi, MPH*More contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 13 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dental DepositsDental PlaqueGingival DiseasesGingivitisInfectionsStomatognathic DiseasesMouth DiseasesPeriodontal DiseasesTooth Diseases

Criteria

Inclusion Criteria: * Aged 13-40 years * Permanent dentition (including first molars) * Willing to undergo orthodontic treatment and follow instructions Exclusion Criteria: * Systemic illness (e.g., diabetes, heart disease, hepatitis) * Pregnant/lactating females * Tobacco use * History of allergies to mouthwash/toothpaste * Use of mouthwash in past 3 months * Abnormal oral morphology or parafunctional habits

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants will receive Listerine mouthwash in unlabelled bottles once daily for 4 weeks.

Group II

Active Comparator
Participants will receive chlorhexidine mouthwash in unlabelled bottles once daily for 4 weeks.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Saidu College of Dentistry

Swāt, PakistanOpen Saidu College of Dentistry in Google Maps
Recruiting
One Study Center