Recruiting

2-phenylethanol Odor Exposure for Epilepsy Apnea Prevention

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What is being tested

2-phenylethanol rose scent

Drug
Who is being recruted

Sudden Unexpected Death in Epilepsy+5

+ Brain Diseases

+ Central Nervous System Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Prevention Study

Early Phase 1
Interventional
Study Start: July 2025
See protocol details

Summary

Principal SponsorVanderbilt University Medical Center
Study ContactBrigitte Jia, BAMore contacts
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2025

Actual date on which the first participant was enrolled.

This study explores the potential of using rose scent as a way to prevent sudden unexpected death in epilepsy (SUDEP), which affects about 1 in 1000 epilepsy patients each year. SUDEP often occurs due to breathing issues during seizures, but the exact cause is still unclear, making it hard to treat. By studying adult epilepsy patients in a hospital setting, researchers aim to see if exposure to the scent of roses can improve respiratory function during seizures, possibly reducing the risk of SUDEP. This study hopes to provide a better understanding of how scents might help manage epilepsy and save lives. Participants in the study will be adults admitted for epilepsy monitoring, where they will wear a non-invasive respiratory belt and undergo routine EEG monitoring. Initially, they will be tested for their ability to identify common scents and their mood will be assessed. Over the course of the study, participants will spend 24 hours in a room with no scent exposure and another 24 hours with rose scent diffused in the room. The researchers will evaluate changes in seizure activity and breathing patterns by comparing data from these two periods. The study carries minimal risks, with rose scent exposure being generally safe and potentially having calming effects.

Official TitleEffect of 2-phenylethanol Odor Exposure on Ictal Apneic Episode Occurrence Rate in Patients With Epilepsy 
Principal SponsorVanderbilt University Medical Center
Study ContactBrigitte Jia, BAMore contacts
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

40 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Sudden Unexpected Death in EpilepsyBrain DiseasesCentral Nervous System DiseasesDeathDeath, SuddenEpilepsyNervous System DiseasesPathologic Processes

Criteria

Inclusion Criteria: * Adult epilepsy patients over the age of 18 * Admission to the inpatient epilepsy monitoring unit (EMU) at Vanderbilt University Medical Center (VUMC) * Undergoing observational EEG monitoring without treatment involving seizure medication changes or other interventions for at least 48 hours Exclusion Criteria: * Patients under the age of 18 * Patients receiving EEG monitoring without interventions from baseline for less than 48 hours * Patients who are not receiving EEG monitoring as a part of their inpatient admission.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Ambient rose scent exposure via aromatherapy diffuser into patient room for 24 hours

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Vanderbilt University Medical Center

Nashville, United StatesSee the location
Recruiting
One Study Center