Recruiting

Bromelain Supplement for Reducing Facial Swelling After Jaw Surgery

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What is being tested

Bromelain

Dietary Supplement
Who is being recruted

Malocclusion

+ Stomatognathic Diseases

+ Tooth Diseases

From 18 to 65 Years
+7 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: September 2025
See protocol details

Summary

Principal SponsorMohamed Bazina
Study ContactEmma E Palmer, DMD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 8, 2025

Actual date on which the first participant was enrolled.

This clinical trial is focused on evaluating the effectiveness of a supplement called Bromelain in reducing facial swelling that often occurs after jaw surgery, also known as orthognathic surgery. The study aims to understand whether Bromelain can lessen the amount of swelling and shorten the duration of swelling following the surgery. This is significant as reducing swelling can improve recovery experiences for patients undergoing this type of surgery. Participants in the study will take a Bromelain supplement once daily for a total of nine days. They will start taking it two days before their surgery and continue for seven days after the surgery. Participants are required to keep a record of when they take the Bromelain supplement and any other medications. They will also attend clinic visits to follow specific procedures before and after the surgery. This study will help determine the safety and effectiveness of Bromelain in managing post-surgical swelling.

Official TitleEffectiveness of Bromelain Supplement in Reduction of Facial Swelling Caused by Orthognathic Surgery
Principal SponsorMohamed Bazina
Study ContactEmma E Palmer, DMD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

200 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

MalocclusionStomatognathic DiseasesTooth Diseases

Criteria

1 inclusion criteria required to participate
undergoing orthognathic surgery

6 exclusion criteria prevent from participating
craniofacial anomalies

incomplete patient data

systemic disease that could affect healing

allergy to latex or pineapple

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
1000mg bromelain supplement once a day, 2 days prior to and 7 days following surgery

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

University of Kentucky

Lexington, United StatesOpen University of Kentucky in Google Maps
Recruiting
One Study Center