Inspiratory Muscle Strength Training for Adults with High Blood Pressure
POWERbreathe K5
Essential Hypertension+2
+ Isolated Systolic Hypertension
+ Cardiovascular Diseases
Treatment Study
Summary
Study start date: October 24, 2025
Actual date on which the first participant was enrolled.This study focuses on understanding how a specific type of breathing exercise, called Inspiratory Muscle Strength Training (IMST), affects blood pressure and blood vessel function in adults who have higher than normal systolic blood pressure. Systolic blood pressure is the pressure in the arteries when the heart beats. The study aims to determine how different levels of this breathing exercise can improve vascular health and potentially lower blood pressure over a period of six weeks. This research is important as it explores a non-drug method to manage high blood pressure, which could provide a new option for individuals seeking alternative or additional treatment methods. Participants in this study will engage in Inspiratory Muscle Strength Training over six weeks. This involves specific breathing exercises designed to strengthen the muscles used in breathing. The study will track changes in blood pressure and the health of blood vessels to understand the impact of the training. There are no specific risks or benefits mentioned, but the study's goal is to evaluate how effective this non-invasive method can be in improving blood pressure and vascular function. Results from this study may guide future treatments for managing high blood pressure without medication.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.144 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Age ≥18 years * Resting SBP ≥120 mmHg as measured during screening 1 \& 2 * Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis. * No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax) * Language: English-speaking, with ability to comprehend study materials and instructions. * Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit. * Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year). Exclusion Criteria: * Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum). * Recent abdominal surgery or presence of an abdominal hernia. * Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea. * Ruptured eardrum or any other condition of the ear. * Markedly elevated left ventricular end-diastolic volume and pressure. * Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition). * Female-Specific: Pregnant or planning to become pregnant during the study period. * Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.3 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Active ComparatorGroup II
Active ComparatorGroup III
Active ComparatorStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location