Recruiting

Intracervical Vasopressin for Hysteroscopic Removal of Retained Conception Products

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What is being tested

Intracervical injection of Vasopressin

+ Intracervical Injection of saline

Drug
Who is being recruted

From 18 to 51 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-ControlledPhase 4
Interventional
Study Start: October 2025
See protocol details

Summary

Principal SponsorPrisma Health-Upstate
Study ContactPatti Parker, BSNMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 30, 2025

Actual date on which the first participant was enrolled.

This study focuses on improving the safety and effectiveness of a procedure used to remove retained products of conception, which can occur after childbirth or miscarriage. The research targets individuals undergoing hysteroscopic surgery, a common method for this removal. Researchers are evaluating whether an injection of a drug called vasopressin into the cervix can help complete the procedure more successfully without needing to switch to a different method due to complications like excessive bleeding. This study is important as it could enhance surgical outcomes and reduce the need for additional interventions during this procedure. Participants in this study will be randomly assigned to receive either the vasopressin injection or a placebo during their hysteroscopic surgery. The main goal is to determine if the use of vasopressin helps to complete the surgery without switching methods. Researchers will assess the surgery's success by monitoring factors like the amount of bleeding, how long the surgery takes, and the volume of fluid used. This information will help determine the effectiveness and safety of using vasopressin in this context.

Official TitleIntracervical Vasopressin for Completion of Hysteroscopic Removal of Retained Products of Conception
Principal SponsorPrisma Health-Upstate
Study ContactPatti Parker, BSNMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 18 to 51 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
Women

Aged 18-51

Undergoing surgical management for retained products of conception, postpartum retained products of conception or 1st trimester missed or incomplete abortion

5 exclusion criteria prevent from participating
Hemodynamic instability

Active hemorrhage- soaking pad/hour

Allergy to vasopressin

Concern for intrauterine arteriovenous malformation

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
Vasopressin- 20 mL of a dilute solution (5 units of Vasopressin in 20cc injectable saline)

Group II

Placebo
20 mL of saline

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

The OB/GYN Center

Greenville, United StatesOpen The OB/GYN Center in Google Maps
Recruiting
One Study Center