Peri-prostatic Neurolysis in High-risk Localized Prostate Cancer

This study focuses on men with high-risk prostate cancer, which has a significant chance of spreading and becoming more serious over time. Often, cancer cells invade the nerves around the prostate, which can lead to more aggressive forms of cancer. Most prostate cancer that spreads moves to the bones, and the nerves connected to the prostate play a role in this process. By targeting these nerves, researchers hope to find new ways to stop the cancer from progressing after initial treatment. Previous studies have shown that using ethanol in small amounts can reduce the nerve density around the prostate, which might help slow down the spread of cancer. In this study, participants will receive either one or two injections of ethanol around the prostate to see which approach is more effective at reducing nerve density. These injections are given to see how well they can prevent the cancer from growing or spreading further. Researchers will monitor the effectiveness of the injections by measuring the changes in nerve density around the prostate. The study aims to refine this technique to maximize its potential benefits while ensuring it remains safe for patients. There may be risks associated with the procedure, but earlier studies have shown that it is generally well-tolerated without serious side effects.