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ECHO Model for Enhancing Chronic Intestinal Failure Care: The LIFT-ECHO Last Mile Project

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Study Aim

This study, ECHO Model for Enhancing Chronic Intestinal Failure Care, aims to improve health services for individuals on home parenteral nutrition. It will measure patients' quality of life using the HPN-PROQ tool, assessing physical health, emotional well-being, social functioning, and treatment burden.

What is being tested

Learn Intestinal Failure Tele-ECHO Program

+ Standard of Care

Behavioral
Who is being recruted

Intestinal Failure+1

+ Digestive System Diseases

+ Gastrointestinal Diseases

Over 5 Years
See all eligibility criteria
How is the trial designed

Services Research Study

Interventional
Study Start: January 2026
See protocol details

Summary

Principal SponsorIcahn School of Medicine at Mount Sinai
Study ContactMarjorie NisenholtzMore contacts
Last updated: December 13, 2025
Sourced from a government-validated database.Claim as a partner

Study start date: January 2, 2026

Actual date on which the first participant was enrolled.

The study aims to evaluate a specific approach called the LIFT-ECHO model to improve care for patients with Chronic Intestinal Failure (CIF). This condition affects the digestive system, making it hard for the body to absorb nutrients properly. The research involves doctors from at least 150 different sites, each overseeing patients with CIF. By understanding how the LIFT-ECHO model can enhance treatment, the study seeks to offer better health outcomes for these patients, potentially leading to improved quality of life and more effective management of the condition. In this trial, doctors are randomly assigned to either continue their usual practices or switch to using the LIFT-ECHO model. This switch is determined by a computer algorithm. Once a doctor starts using the LIFT-ECHO model, they continue with it throughout the study. Initially, there is a 6-month period where normal practices are observed, followed by a 2-month introduction of the LIFT-ECHO model. After this, patients continue to receive treatment under the new approach for a year. The study looks at how patient care improves over time, helping to determine the model's effectiveness in managing CIF.

Official TitleImproving Outcomes in Chronic Intestinal Failure Using the ECHO Model: The LIFT-ECHO Last Mile Project 
NCT07094308
Principal SponsorIcahn School of Medicine at Mount Sinai
Study ContactMarjorie NisenholtzMore contacts
Last updated: December 13, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

150 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Services Research Study

These studies look at how healthcare is delivered, managed, and organized. They aim to improve care quality, patient experience, and access to treatment.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 5 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Intestinal FailureDigestive System DiseasesGastrointestinal DiseasesIntestinal Diseases

Criteria

Inclusion Criteria: * CIF patient participants must meet the following criteria in order to be considered eligible for participation: * Individuals of adult age (18 years or older), including pregnant women or Individuals of age \> 5 years with parental consent and patient assent. * Diagnosis of chronic intestinal failure (ie. on PN \>6 months with no malignancy, no HIV and a malabsorption or post-surgical diagnosis) * Currently receiving PN from a homecare infusion service company * Physician Inclusion Criteria: * Physician participants must meet the following criteria in order to be considered eligible for participation: * Individuals of adult age (18 years or older), including pregnant women * Hold an MD or DO degree * Be a licensed physician prescriber with a homecare infusion service company Exclusion Criteria: * Participants meeting one or more of the following criteria will be excluded from participation: * Adults unable to consent (individuals with impaired decision-making capacity) * Prisoners * Children \> 5 years who dissent

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Dyads consisting of a prescribing physician and one or more of their patients receiving parenteral nutrition (PN). Physicians in this arm will be invited to participate but would not yet have received the Tele-Mentoring (LIFT-ECHO) focused on the management of chronic intestinal failure. Patients of these physicians will be followed for a baseline period of 6 months (Control period) to assess evolution in clinical outcomes and patient-reported quality of life.

Group II

Experimental
Dyads consisting of a prescribing physician and one or more of their patients receiving parenteral nutrition (PN). Physicians in this arm will participate in the LIFT-ECHO program. After patients complete a baseline period of 6 months (Control period), their physician receives the intervention (LIFT-ECHO).

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 5 locations

Suspended

Icahn School of Medicine at Mount Sinai

New York, United StatesSee the location
Suspended

New York Academy of Medicine (NYAM)

New York, United States
Suspended

Rhode Island Hospital

Providence, United States
Suspended

University of Utah

Salt Lake City, United States
Recruiting soon5 Study Centers