Recruiting soon

Compare Additively vs Subtractively Manufactured Implant Supported Fixed Dental Prostheses

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Study Aim

This study compares the clinical success of additively and subtractively manufactured implant-supported fixed dental prostheses, focusing on the absence of complications over the observation period.

What is being tested

AM manufacturing method

+ SM manufacturing method

Device
Who is being recruted

Over 20 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2025
See protocol details

Summary

Principal SponsorHarvard Medical School (HMS and HSDM)
Study ContactKevser Pala, Dr.med.dent
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 30, 2025

Actual date on which the first participant was enrolled.

This clinical trial aims to compare two different ways of making dental crowns for patients who need a strong and permanent crown on the back teeth. The study involves patients who will receive implant-supported crowns made either by adding materials layer by layer (additive manufacturing) or by cutting away from a solid block (subtractive manufacturing). The trial takes place at Harvard School of Dental Medicine and the University of Zurich's Center of Dental Medicine. Understanding which method results in better crowns could improve dental treatments and outcomes for patients requiring such dental implants. Participants in the study receive a single implant-supported crown created by one of the two methods, depending on their group assignment. After receiving their crowns, participants are monitored for three years to evaluate how well the crowns perform. The study checks the crowns' clinical performance, including their technical, biological, and aesthetic aspects. Both the dental technicians and patients will report their outcomes, ensuring a comprehensive assessment of the crowns' effectiveness and satisfaction. This research could highlight significant differences in durability and patient satisfaction between the two manufacturing methods.

Official TitleAdditively (AM) Versus Subtractively (SM) Manufactured Implant Supported Fixed Dental Prostheses (iFDPs)
NCT07090863
Principal SponsorHarvard Medical School (HMS and HSDM)
Study ContactKevser Pala, Dr.med.dent
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 20 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

6 inclusion criteria required to participate
Signed Informed Consent Form in English language

≥ 20 years of age

In need of at least one definitive screw retained premolar or molar iFDP on an existing dental implant (Straumann AG)

Presence of at least one adjacent tooth at the implant site

Show More Criteria

3 exclusion criteria prevent from participating
Pregnant or lactating women

Known or suspected non-compliance, drug or alcohol abuse

Severe periodontal and peri-implant disease

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
additively manufactured implant-supported prostheses

Group II

Active Comparator
subtractively manufactured implant-supported prostheses

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

Harvard School of Dental Medicine

Boston, United StatesOpen Harvard School of Dental Medicine in Google Maps
Suspended

Center of Dental Medicine, University of Zurich

Zurich, Switzerland
Recruiting soon2 Study Centers