Trelagliptin and Sitagliptin for Type II Diabetes

Type 2 diabetes is a long-lasting condition where the body struggles to keep blood sugar levels in check, leading to various health problems if not managed well. Many people with this condition take a common medication called metformin, but it doesn't always work perfectly on its own. This study is exploring whether a different approach using two drugs, Trelagliptin and Sitagliptin, might help. Both of these drugs belong to a class of medicines that help control blood sugar by affecting a hormone related to insulin. Trelagliptin is taken once a week, while Sitagliptin is taken daily. The study focuses on patients who haven't reached their blood sugar goals with just metformin, aiming to see if Trelagliptin's less frequent dosing might be just as effective or even better than Sitagliptin, while also being more convenient. Participants in the study are divided into two groups: one group takes Trelagliptin once a week, and the other takes Sitagliptin every day, both for three months, while continuing their metformin treatment. Their blood sugar levels are monitored by checking a specific measure called HbA1c before and after the treatment period, along with other blood sugar tests each month. Participants keep a diary to track their medication use and share their experiences through interviews and a satisfaction questionnaire. This helps researchers understand how well patients stick to their treatment and how satisfied they are with their therapy. The study takes place at a hospital in Pakistan and aims to provide insights that could improve diabetes treatment approaches.