Recruiting soon

Deep Cervical Lymphatic Venous Anastomosis for Alzheimer's Disease Treatment

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
Study Aim

This observational study examines the impact of Deep Cervical Lymphatic Venous Anastomosis on Alzheimer's disease. We will assess the change in Clinical Dementia Rating-Sum of Boxes score at 12 months after surgery and the incidence of perioperative complications within 7 days.

What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Alzheimer Disease+6

+ Mental Disorders

+ Brain Diseases

Over 18 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: July 2025
See protocol details

Summary

Principal SponsorBeijing Tiantan Hospital
Study ContactYuesong PanMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 30, 2025

Actual date on which the first participant was enrolled.

Alzheimer's Disease is a common condition that affects many older adults, causing problems with memory and thinking. As the number of people with Alzheimer's is expected to grow significantly, researchers are exploring new treatments. This study focuses on a procedure called deep cervical lymphatic venous anastomosis (DC-LVA) as a potential treatment to improve cognitive function in individuals with Alzheimer's. The study aims to assess whether this procedure is effective and safe, particularly since many existing treatments have not shown strong results. By focusing on this approach, the researchers hope to find a more effective method for managing Alzheimer's symptoms. Participants in the study will undergo the DC-LVA procedure and will be monitored over a two-year period. They will have several check-ups, including interviews and tests, at different intervals to evaluate their cognitive abilities and daily functioning. The study will measure changes in scores related to dementia and cognitive function, as well as brain scans to track amyloid levels, which are linked to Alzheimer's. Safety is also a focus, with any complications being carefully recorded. Additionally, the study will explore various biomarkers and brain imaging results to understand the procedure's impact on Alzheimer's-related changes in the brain.

Official TitleDeep Cervical Lymphatic Venous Anastomosis in Treatment of Alzheimer's Disease: A Multicenter, Prospective, Registry (CLEAN-AD Registry)
NCT07058129
Principal SponsorBeijing Tiantan Hospital
Study ContactYuesong PanMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

814 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Alzheimer DiseaseMental DisordersBrain DiseasesCentral Nervous System DiseasesDementiaNervous System DiseasesNeurodegenerative DiseasesNeurocognitive DisordersTauopathies

Criteria

4 inclusion criteria required to participate
Age ≥ 18 years, male or famale.
Diagnosed with AD according to the NIA-AA criteria.
Patients who have received DC-LVA treatment;
Signed informed consent (by the subject or their relative, and caregiver)
2 exclusion criteria prevent from participating
Severe neurological deficits in limb movement, language, vision, hearing, or consciousness, or any condition that the investigator determines may prevent the completion of cognitive function assessments.
The subject lacks a stable and reliable caregiver to accompany with them during entire study follow-up visits.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Beijing Tiantan Hopital, Capital Medical University

Beijing, ChinaOpen Beijing Tiantan Hopital, Capital Medical University in Google Maps
Recruiting soonOne Study Center
Deep Cervical Lymphatic Venous Anastomosis for Alzheimer's Disease Treatment | PatLynk