Ketorolac and Gabapentin's Impact on Pain Relief in Total Knee Arthroplasty

This study is exploring how effective a pre-surgery dose of two medications, Ketorolac and Gabapentin, can be in reducing pain for patients undergoing a specific type of knee surgery called unilateral total knee arthroplasty (TKA). This surgery is often used to relieve pain from arthritis when other treatments haven’t worked. After this surgery, patients usually experience a lot of pain. By giving these medications before the surgery, researchers hope to prevent the body from becoming overly sensitive to pain, which can lead to less pain immediately after the surgery and potentially reduce the risk of developing long-term pain. This approach, called pre-emptive analgesia, aims to improve recovery by managing pain effectively from the start. In this study, participants will receive a combination of Ketorolac and Gabapentin before their knee surgery. Ketorolac is a type of non-steroidal anti-inflammatory drug (NSAID) that helps reduce pain and swelling, while Gabapentin is used to control nerve pain. Participants won't know if they are receiving the study medications or not, as this trial is double-blinded. Researchers will measure how well this combination works by looking at the levels of pain experienced by patients after the surgery and how quickly they recover. This study could lead to better pain management strategies for knee surgery patients, helping them recover faster and spend less time in the hospital.