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Comparative Study of Lidocaine and Ketamine Infusion for Postoperative Pain in Thyroidectomy Patients

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Study Aim

This study compares the use of lidocaine and ketamine infusions to manage postoperative pain in thyroidectomy patients, evaluating their effect on pain reduction.

What is being tested

group L : will receive lidocaine

+ group k : will receive Ketamine

+ group c: will recieve .9% saline

Drug
Who is being recruted

Endocrine System Diseases

+ Thyroid Diseases

From 18 to 75 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Placebo-Controlled
Interventional
Study Start: June 2025
See protocol details

Summary

Principal SponsorSohag University
Study ContactMario N Ishak, ResidentMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 11, 2025

Actual date on which the first participant was enrolled.

This clinical trial investigates how two different medications, lidocaine and ketamine, might help reduce pain after thyroid surgery, known as a thyroidectomy. The goal is to determine which medication is more effective at providing pain relief after the surgery. Patients undergoing thyroidectomy often experience postoperative pain, and finding the most effective way to manage this pain can improve recovery and comfort. Lidocaine and ketamine are both known for their pain-relieving properties, and this study seeks to identify which one offers better relief for patients. Participants in the study receive either lidocaine or ketamine through an intravenous (IV) drip during their surgery. This means the medication is delivered directly into the bloodstream through a vein. The study then monitors the level of pain relief each patient experiences after their surgery to evaluate the effectiveness of each drug. By comparing the pain levels reported by patients, the study aims to determine which drug provides better postoperative pain control. There are no specific outcomes listed, but the general focus is on the quality of pain relief provided by each medication.

Official TitleEffects of Perioperative Intravenous Lidocaine Infusion Versus Ketamine Infusion For Postoperative Analgesia in Patients Undergoing Thyroidectomy : A Randomized Controlled Trial
NCT07045870
Principal SponsorSohag University
Study ContactMario N Ishak, ResidentMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 75 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Endocrine System DiseasesThyroid Diseases

Criteria

3 inclusion criteria required to participate
age from 18 to 75 years old

both sexes

scheduled for thyroidectomy

6 exclusion criteria prevent from participating
toxic goiter

BMI) exceeding 30 kg / m2

un controlled hypertension

sever liver or kidney disorders

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

33.333% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
lidocaine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

Group II

Active Comparator
Ketamine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

Group III

Placebo
.9% saline will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Sohag university hospital

Sohag, EgyptOpen Sohag university hospital in Google Maps
Recruiting
One Study Center
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