Recruiting

Cerebrolysin Impact on Early Ischemic Stroke Rehabilitation

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Study Aim

This study explores if Cerebrolysin can enhance early rehabilitation in individuals who have experienced ischemic stroke, by observing changes in their upper limb function after 90 days.

What is being tested

Cerebrolysin treatment

+ Standard treatment (including neurorehabilitation) of acute ischemic stroke

DrugOther
Who is being recruted

Ischemic Stroke+5

+ Brain Diseases

+ Cardiovascular Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: June 2025
See protocol details

Summary

Principal SponsorUniversity Medical Centre Ljubljana
Study ContactMatija Zupan, MD, PhDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 13, 2025

Actual date on which the first participant was enrolled.

Cerebrolysin is a drug made from pig brain proteins and is used to treat various brain conditions, including strokes. This study aims to see how effective Cerebrolysin is in helping patients recover from moderate to severe strokes, specifically in a hospital setting in Ljubljana. The study hopes to show whether adding Cerebrolysin to the usual care for stroke patients can improve their recovery and reduce their neurological impairments, both when they leave the hospital and 90 days later. Participants in the study will have had a recent stroke and will either receive standard stroke care alone or standard care plus Cerebrolysin. Those receiving Cerebrolysin will be given the drug through an IV infusion daily for 10 days. The researchers will then compare the recovery progress between the two groups to determine if Cerebrolysin provides any additional benefit. This involves looking at how much their neurological symptoms improve by the time they are discharged and after three months. The study ensures that the drug is administered safely, using sterile equipment for each infusion.

Official TitleEffect of Cerebrolysin on Early Rehabilitation After Ischemic Stroke at the Department of Vascular Neurology and Intensive Neurological Therapy (KOVNINT), University Medical Centre Ljubljana
NCT07043686
Principal SponsorUniversity Medical Centre Ljubljana
Study ContactMatija Zupan, MD, PhDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Ischemic StrokeBrain DiseasesCardiovascular DiseasesCentral Nervous System DiseasesCerebrovascular DisordersNervous System DiseasesVascular DiseasesStroke

Criteria

Inclusion Criteria: Being able to perform ARAT test Signed informed consent Both sexes, age not specified Acute ischemic stroke confirmed by imaging NIHSS score 6-12 No prior stroke or disability (mRS 0 before stroke) \- Exclusion Criteria: Not being able to perform ARAT test * Previous stroke or disability (mRS \> 0) * The patient unable to understand instructions

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
The patients in Arm 1 will be treated with cerebrolysin and standard treatment.

Group II

The patients in Arm 2 will receive standard treatment only.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

UMC Ljubljana - Department of Vascular Neurology and Intensive Neurological Therapy (KOVNINT)

Ljubljana, SloveniaOpen UMC Ljubljana - Department of Vascular Neurology and Intensive Neurological Therapy (KOVNINT) in Google Maps
Recruiting
One Study Center