BioMicroMicronutrient Bioavailability Study: Vitamin K Focus

This study investigates how different forms of vitamin K are absorbed in the body. Vitamin K is essential for blood clotting and bone health. The study focuses on four specific types of vitamin K, referred to as vitamers: 13C-PK, 13C-MK-4, 13C-MK-7, and 13C-MK-9. Understanding the bioavailability, or how well these vitamins are absorbed, could help improve dietary recommendations and supplement formulations, particularly for those who may have deficiencies or need specific types of vitamin K for health reasons. Participants in the study follow specific instructions to prepare, such as avoiding certain foods like sweet corn, beetroot, and spinach, and taking a vitamin D supplement. During the test periods, participants fast and then consume a meal containing a labeled vitamin K vitamer. Blood samples are taken at various intervals after the meal to track how the vitamin is absorbed over time. The study involves several test periods, and between these periods, participants have washout periods where they refrain from consuming the labeled vitamin K to prevent overlap. This research could provide valuable insights into which forms of vitamin K are most beneficial and how to optimize their use.