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Liraglutide Response Investigation in Maturity-onset Diabetes of the Young Patients with Enteroendocrine Dysfunction and Metabolism Issues

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Study Aim

This study investigates how the drug Liraglutide affects blood sugar control and weight in adults with maturity-onset diabetes who have issues with enteroendocrine function. We will measure your Hemoglobin A1c and calculate your Body Mass Index to evaluate the effects of the treatment.

What is being tested

Liraglutide

Drug
Who is being recruted

Diabetes Mellitus+3

+ Diabetes Mellitus, Type 2

+ Endocrine System Diseases

Over 10 Years
+14 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: May 2025
See protocol details

Summary

Principal SponsorMansa
Study ContactMansa Krishnamurthy, M.D.
Last updated: December 18, 2025
Sourced from a government-validated database.Claim as a partner

Study start date: May 8, 2025

Actual date on which the first participant was enrolled.

This study focuses on individuals with a specific type of diabetes called Maturity-onset Diabetes of the Young (MODY). The goal is to understand how these patients' bodies process hormones and nutrients before and after they start taking a medication called liraglutide. Researchers hope that liraglutide will not only help improve blood sugar levels and weight but also alleviate digestive symptoms that some MODY patients experience. This research could lead to better treatment plans and care for people with this type of diabetes. Participants in the study will first undergo tests to measure their hormone levels and metabolism. After starting the liraglutide treatment, which is usually given as an injection, these tests will be repeated to see how their bodies respond. The study will track changes in blood sugar control, weight, and gastrointestinal symptoms. If certain individuals show significant improvement, scientists will use their cells to study why their bodies respond well to the medication. This approach seeks to uncover the underlying reasons for digestive issues in MODY patients and improve future treatments.

Official TitleInvestigating Enteroendocrine Dysfunction, Metabolism, and Response to Liraglutide in Patients With Maturity-onset Diabetes of the Young (MODY) 
NCT07029009
Principal SponsorMansa
Study ContactMansa Krishnamurthy, M.D.
Last updated: December 18, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 10 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Diabetes MellitusDiabetes Mellitus, Type 2Endocrine System DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesGlucose Metabolism Disorders

Criteria

2 inclusion criteria required to participate
Diagnosis of MODY via genetic testing

HgbA1c >6.5%

12 exclusion criteria prevent from participating
History of anaphylaxis to GLP-1 receptor agonists

Already taking GLP-1 receptor agonists

on medications within the stimulant class

have had bariatric surgery

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants in this group will start with a low dose of Liraglutide, gradually increasing to a final dose of 1.8 mg daily. If side effects occur, the dose may be reduced to 1.2 mg daily.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Cincinnati Children's Hospital Medical Center

Cincinnati, United StatesSee the location
Recruiting
One Study Center