Tolododekin Alfa (ANK-101) and Anti-PD-1/PD-L1 Antibody Combination Treatment for Advanced Non-Small Cell Lung Cancer
This early-stage study examines how the combination of Tolododekin Alfa (ANK-101) and Anti-PD-1/PD-L1 antibody treatment affects advanced non-small cell lung cancer. The goal is to assess its impact on tumor shrinkage.
tolododekin alfa
+ Cetrelimab
Bronchial Neoplasms+7
+ Carcinoma, Bronchogenic
+ Carcinoma, Non-Small-Cell Lung
Treatment Study
Summary
Study start date: October 22, 2025
Actual date on which the first participant was enrolled.This study focuses on testing a new combination of treatments for people with advanced non-small cell lung cancer (NSCLC). It looks at the effects of a drug called tolododekin alfa (ANK-101) when used with another type of medicine that targets proteins known as PD-1 or PD-L1, which are involved in how cancer cells evade the immune system. There are two groups involved: one group includes patients whose cancer has worsened after receiving the usual treatments, and the other group includes patients who have not yet received treatment for their advanced lung cancer. The goal is to find out if this new combination can provide better outcomes for patients who have limited options. Participants will receive the treatments as part of the study to see how well they work together. The study observes how the body responds to this combination and checks for any potential improvements in controlling the cancer. Researchers will closely monitor participants to understand the safety and effects of these medications, ensuring that any risks are managed and any benefits are maximized. Although specific outcomes are not listed, the study aims to gather essential information to inform future treatments for lung cancer.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.60 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 5 locations
Barbara Ann Karmanos Cancer Hospital
Detroit, United StatesRoswell Park Comprehensive Cancer Center
Buffalo, United StatesIcahn School of Medicine at Mount Sinai
New York, United States