Recruiting soon

LLM-Facilitated Cognitive Debiasing in Musculoskeletal Care

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

LLM-facilitated cognitive debiasing aid

Behavioral
Who is being recruted

Over 18 Years
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: June 2025
See protocol details

Summary

Principal SponsorUniversity of Texas at Austin
Study ContactEmily H Jaarsma, MD
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Study start date: June 23, 2025

Actual date on which the first participant was enrolled.

This study focuses on improving how patients interpret and manage musculoskeletal pain or dysfunction. Often, people quickly form beliefs about their symptoms that may not align with the actual medical condition, leading to unnecessary stress and medical procedures. The trial aims to test whether using a Large Language Model (LLM)-facilitated cognitive debiasing strategy can help patients understand their symptoms better compared to just receiving LLM-generated diagnostic feedback. This approach could lead to more accurate symptom evaluation and improve the overall healthcare experience by addressing the common challenge of misinterpretation in musculoskeletal care. Participants in this study will engage with an LLM, such as ChatGPT, which processes their symptom descriptions and beliefs to create clear summaries that help them identify and reconsider their thought patterns. The LLM can also assist healthcare providers by highlighting any potentially unhelpful beliefs before consultations, promoting better communication. The study compares this structured debiasing intervention with standard LLM-generated diagnostic feedback to see which method more effectively supports accurate symptom understanding and improves patient care. There are no specified risks or benefits outlined for participants, but the study aims to enhance the quality of decision-making and patient experiences.

Official TitleComparison of a Large Language Model (LLM)-Facilitated Cognitive Debiasing Strategy Versus LLM-Generated Diagnostic Feedback Alone in Musculoskeletal Specialty Care: A Randomized Controlled Trial 
NCT07022769
Principal SponsorUniversity of Texas at Austin
Study ContactEmily H Jaarsma, MD
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

150 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

Inclusion Criteria: * Adults (18+) * New or return patient seeking musculoskeletal specialty care at an Orthopedic outpatient clinic * Total combined score on the 6 feelings and thoughts items of \> 10\* (Appendix 3 of study protocol) * English-speaking * Pre-visit diagnosis of chronic, non-traumatic musculoskeletal condition (including, but not limited to: osteoarthritis, carpal tunnel syndrome, trigger digit, Dupuytren's, De Quervain's, lateral epicondylitis) Exclusion Criteria: * Any impairment preventing completion of surveys on a tablet

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
The intervention is a four-part, tablet-based cognitive debiasing aid that uses a Large Language Model (LLM) to help patients reflect on and re-evaluate their beliefs about their symptoms prior to a musculoskeletal specialty care visit. Patient responses are summarized by the LLM in supportive language to promote flexible thinking, and a separate LLM-generated summary of potential unhelpful beliefs is shared with the clinician to guide empathic, individualized communication.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Dell Medical School, University of Texas at Austin

Austin, United StatesSee the location
Recruiting soonOne Study Center