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BalneotherapyBalneotherapy's Impact on Inflammation and Quality of Life in Knee Osteoarthritis

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What is being tested

Balneotherapy

+ home exercise program

Other
Who is being recruted

Arthritis+3

+ Joint Diseases

+ Musculoskeletal Diseases

Over 50 Years
+12 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2025
See protocol details

Summary

Principal SponsorAhi Evran University Education and Research Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2025

Actual date on which the first participant was enrolled.

The study aims to explore the effects of balneotherapy, which involves treatments using mineral-rich water, on knee osteoarthritis. Specifically, the research focuses on how this therapy might reduce inflammation and improve quality of life for adults aged 50 to 80 who have moderate to severe knee osteoarthritis. This condition often leads to joint pain and stiffness, and the study seeks to understand if balneotherapy can lower harmful substances in the blood that contribute to inflammation and joint damage. By potentially reducing these markers, the treatment could offer a new way to manage symptoms and slow disease progression, providing a valuable option for those affected by this common and often painful condition. Participants in the study are randomly divided into two groups. One group receives balneotherapy sessions at a thermal center for 15 to 20 minutes each morning, five days a week, over three weeks. The other group follows a home exercise routine and uses pain relief medication like paracetamol. Both groups receive educational material on managing knee osteoarthritis. The study measures changes in specific blood markers before and after treatment to assess the effects of the therapies. Statistical tests will help determine if there are significant differences between the groups, offering insights into the potential benefits of balneotherapy for knee osteoarthritis.

Official TitleThe Effect of Balneotherapy on the Inflammatory Process and Quality of Life in Patients With Knee Osteoarthritis
NCT07008937
Principal SponsorAhi Evran University Education and Research Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

ArthritisJoint DiseasesMusculoskeletal DiseasesOsteoarthritisRheumatic DiseasesOsteoarthritis, Knee

Criteria

4 inclusion criteria required to participate
Being over 50 years old

Patients diagnosed with knee OA

At stages 2-to-4 according to the Kellgren- Lawrence classification

Patients who agree to receive balneotherapy treatment

8 exclusion criteria prevent from participating
Neoplasia

Infections

Uncompensated cardiac or pulmonary problems

Total knee arthroplasty

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Group 1 -Patients in the research group will receive geothermal treatment (spa therapy) for 20 minutes daily for 15 days.

Group II

Group 2- Patients in the control group will be followed up with only a home exercise program

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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