Recruiting

Comparison of Surgical Techniques for Horizontal Ridge Bone Augmentation

What is being tested

khoury block graft

+ urban sausage technique

+ non resorbable membrane

Procedure

Who is being recruted

Bone Diseases+5

+ Bone Resorption

+ Stomatognathic Diseases

From 18 to 70 Years

+2 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Treatment Study

Interventional

Study Start: November 2024

See protocol details

Summary

Principal SponsorBritish University In Egypt

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: November 1, 2024

Actual date on which the first participant was enrolled.

This clinical trial aims to compare three different surgical techniques for enhancing bone growth in the jaw where there has been significant bone loss due to missing teeth. The study targets adults between the ages of 18 and 70 who have lost two or more teeth in the back of the lower jaw and have a narrow bone width in that area. This research is crucial as it seeks to determine the most effective method for bone regeneration, which is a necessary step before placing dental implants in patients who have experienced severe bone loss. The findings could improve dental care by identifying the best approach for creating enough bone to support implants, reducing complications, and enhancing patient outcomes. Participants in this study will be randomly assigned to one of three groups, each receiving a different technique for bone augmentation. The first group will receive a bone block graft using the Khoury technique, the second group will undergo the Urban Sausage technique using a resorbable membrane, and the third group will use a non-resorbable PTFE membrane. Each technique involves specific surgical steps to add bone material and secure it in place. Results will be measured using advanced imaging to assess bone thickness and volume before and six months after the procedures. Participants will also report on pain and discomfort after surgery. The study evaluates not only the bone growth but also patient comfort and any potential complications to determine the most effective and patient-friendly method.

Official TitleEffects of Three Different Surgical Techniques for Horizontal Ridge Bone Augmentation: A Superiority Randomized Clinical Trial

NCT07002931

Principal SponsorBritish University In Egypt

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

63 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Bone DiseasesBone ResorptionStomatognathic DiseasesMouth DiseasesMusculoskeletal DiseasesPeriodontal DiseasesAlveolar Bone LossPeriodontal Atrophy

Criteria

1 inclusion criteria required to participate

Have two or more missing teeth in the posterior mandibular segment; 2) The alveolar ridge in the edentulous site of the selected patients will have a buccolingual width of less than 4mm; 3) Sufficient vertical bone height; 4) Free of any local or systemic condition that may contraindicate ridge expansion procedure

1 exclusion criteria prevent from participating

1) Patients taking any medication that may interfere with bone healing or bone biology; 2) Patients with any systemic disease that may affect bone healing; 3) Any patients with any previous bone grafting procedure at the site of interest; 4) Smokers; 5) Patient's that have been diagnosed with periodontal disease, as sufficient ridge height would be improbable.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Active Comparator

Bone blocks will be harvested from the retromolar area after measuring of the size required and measuring of the donor site anatomy. Piezoelectric device will be used to perform the graft osteotomy. The osteotomy lines will be connected and the graft will be mobilized using a bibeveled chisel and mallet. Sharp bony edges will be smoothened and the donor defect was packed with gelatin sponges. The bone block margins will be smoothened and separated into two thinner bone shells using titanium disk with copious saline irrigation. The blocks will be fixed into the recipient site buccally using at least two microscrews leaving a gap to be filled with bone graft. Particulate xenogenic bone graft will be mixed with the autogenous bone chips (50% Xenograft: 50% Autogenous graft) to fill the gap between the buccal bone plate and the fixed bone shells. The augmented site will be covered with a pericardium membrane.

Group II

Active Comparator

A resorbable pericardium membrane will be fixed with titanium pins on the lingual bone plate (2-3mm from the bone crest) and on the buccal bone plate allowing for packing of particulate mix of bone graft (50% Xenograft: 50% Autogenous graft). Overfilling of the graft will be respected to compensate for future resorption. The membrane will be stretched over the graft ensuring maximum immobilization of the graft.

Group III

Active Comparator

A non-resorbable polytetrafluoroethylene (PTFE) membrane will be fixed with titanium tacks on the lingual bone plate (2-3mm from the bone crest) and on the buccal bone plate allowing for packing of particulate mix of bone graft (50% Xenograft: 50% Autogenous graft). Overfilling of the graft will be respected to compensate for future resorption.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Faculty of dentistry, British university of egypt

Cairo, EgyptOpen Faculty of dentistry, British university of egypt in Google Maps

Recruiting

One Study Center