REPEAT-AFTechniques for Repeat Ablation in Persistent Atrial Fibrillation
Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI)
+ Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)
Arrhythmias, Cardiac+3
+ Atrial Fibrillation
+ Cardiovascular Diseases
Other Study
Summary
Study start date: March 18, 2026
Actual date on which the first participant was enrolled.Atrial fibrillation, or AF, is a common issue where the heart beats irregularly. Sometimes, doctors use a procedure called ablation to correct this problem, but it may not always be effective. This study is exploring whether adding a new step to the standard ablation procedure, which involves treating an additional part of the heart called the left atrial posterior wall, can lead to better outcomes. The focus is on people who have already undergone an ablation but did not achieve the desired results. By comparing this new method to the usual procedure, the study aims to see if it can improve the overall well-being of individuals with persistent AF. Participants in this study will undergo a repeat ablation procedure. Some will have the standard ablation, known as pulmonary vein isolation, while others will receive the additional treatment to the left atrial posterior wall. The study will measure how effective these procedures are by evaluating the participants' heart rhythm and overall health improvements following the treatment. The goal is to determine which method provides better relief from symptoms and improves the quality of life for those affected by persistent atrial fibrillation. Potential benefits could include a more stable heart rhythm and improved daily functioning.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.630 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Other Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Group II
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
University of Rochester Clinical Cardiovascular Research Center
Rochester, United StatesOpen University of Rochester Clinical Cardiovascular Research Center in Google Maps