Enrolling by invitation

REPEAT-AFTechniques for Repeat Ablation in Persistent Atrial Fibrillation

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What is being tested

Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI)

+ Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)

Procedure
Who is being recruted

Arrhythmias, Cardiac+3

+ Atrial Fibrillation

+ Cardiovascular Diseases

Over 18 Years
+26 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: March 2026
See protocol details

Summary

Principal SponsorUniversity of Rochester
Last updated: March 24, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 18, 2026

Actual date on which the first participant was enrolled.

Atrial fibrillation, or AF, is a common issue where the heart beats irregularly. Sometimes, doctors use a procedure called ablation to correct this problem, but it may not always be effective. This study is exploring whether adding a new step to the standard ablation procedure, which involves treating an additional part of the heart called the left atrial posterior wall, can lead to better outcomes. The focus is on people who have already undergone an ablation but did not achieve the desired results. By comparing this new method to the usual procedure, the study aims to see if it can improve the overall well-being of individuals with persistent AF. Participants in this study will undergo a repeat ablation procedure. Some will have the standard ablation, known as pulmonary vein isolation, while others will receive the additional treatment to the left atrial posterior wall. The study will measure how effective these procedures are by evaluating the participants' heart rhythm and overall health improvements following the treatment. The goal is to determine which method provides better relief from symptoms and improves the quality of life for those affected by persistent atrial fibrillation. Potential benefits could include a more stable heart rhythm and improved daily functioning.

Official TitleComparative Effectiveness of Different Techniques for Repeat Ablation After Failed Initial Ablation for Persistent Atrial Fibrillation
NCT06988202
Principal SponsorUniversity of Rochester
Last updated: March 24, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

630 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Arrhythmias, CardiacAtrial FibrillationCardiovascular DiseasesHeart DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Criteria

5 inclusion criteria required to participate
One prior PVI ablation procedure > 3 months prior for persistent AF

Recurrent paroxysmal or persistent symptomatic AF confirmed on ECG despite prior PVI

Eligible for repeat ablation procedure

Willingness to comply with all post-procedural follow-up requirements and to sign informed consent

Show More Criteria

21 exclusion criteria prevent from participating
Inability to undergo AF catheter ablation (e.g., presence of a left atrial thrombus)

Prior ablation that included non-PVI LA ablation, or more than one prior PVI ablation procedure for persistent AF

Prior surgical ablation for AF

Contraindication to systematic anticoagulation

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Group II

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Rochester Clinical Cardiovascular Research Center

Rochester, United StatesOpen University of Rochester Clinical Cardiovascular Research Center in Google Maps
Enrolling by invitationOne Study Center