Recruiting soon

Subgingival Instrumentation Effects on Stress Load in Periodontitis Patients

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Sub-gingival instrumentation

Procedure
Who is being recruted

Chronic Disease+7

+ Inflammation

+ Stomatognathic Diseases

From 30 to 50 Years
+7 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: June 2025
See protocol details

Summary

Principal SponsorPostgraduate Institute of Dental Sciences Rohtak
Study ContactRajinder K Sharma, MDSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 10, 2025

Actual date on which the first participant was enrolled.

This study investigates how subgingival instrumentation, a common dental procedure, affects the overall stress burden, known as allostatic load, in individuals with periodontitis, a severe gum disease. Stress is linked to many chronic health problems, and its effects can disrupt the body's normal functioning, leading to conditions like high blood pressure and diabetes. In the mouth, stress can worsen gum diseases by affecting the immune system and encouraging harmful habits like smoking or neglecting oral hygiene. This research is important because it seeks to clarify how stress impacts gum disease and overall health, potentially leading to better care for people with periodontitis by addressing the role of stress and improving both oral and general health outcomes. Participants in the study will undergo subgingival instrumentation, which involves cleaning below the gum line to remove plaque and tartar. This procedure will help researchers measure changes in stress-related biomarkers, such as cortisol levels and other indicators of bodily stress responses. The study aims to understand whether this dental treatment can influence the body's stress markers and improve gum health. By examining these effects, the study hopes to provide insights into the relationship between stress, oral health, and systemic health, potentially revealing new ways to manage periodontitis and reduce its long-term impacts on health.

Official TitleImpact of Subgingival Instrumentation on Allostatic Load in Periodontitis
NCT06978712
Principal SponsorPostgraduate Institute of Dental Sciences Rohtak
Study ContactRajinder K Sharma, MDSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

112 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 30 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Chronic DiseaseInflammationStomatognathic DiseasesMouth DiseasesPathologic ProcessesPeriodontal DiseasesPeriodontitisPathological Conditions, Signs and SymptomsDisease AttributesChronic Periodontitis

Criteria

2 inclusion criteria required to participate
Patients with age group 30-50 years diagnosed with generalized periodontitis.

Presence of minimum 20 teeth excluding third molars.

5 exclusion criteria prevent from participating
Periodontal treatment within last 6 months

History of antibiotic use within the previous 3 months

History of use of steroid, immunosuppressive and psychiatric drugs

Pregnant and lactating women

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Stage II/III Periodontitis

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

PGIDS

Rohtak, IndiaOpen PGIDS in Google Maps
Recruiting soonOne Study Center