Trop2-targeting NIR-II Probe for Non-Muscle-Invasive Bladder Cancer

This study is designed to improve the way non-muscle-invasive bladder cancer is identified during surgery. It focuses on using a special fluorescent probe called TTP-ICG to help doctors distinguish between cancerous and nearby non-cancerous tissues. This is important because accurately identifying cancerous tissue can lead to more effective surgeries and better outcomes for patients. By enhancing the precision of cancer detection, this study aims to address the current challenge of differentiating cancerous tissues, which can sometimes be difficult with traditional methods. Participants in the study undergo surgical treatment for bladder cancer. After surgery, the removed tissues are treated with a TTP-ICG solution and then analyzed. The tissues are soaked in the solution for a short time, after which they are rinsed and dried. A special imaging system captures images of the tissues, allowing researchers to measure fluorescent signals that help determine if the tissue is cancerous. The study evaluates the intensity of these signals to see how well the probe can differentiate between cancerous and non-cancerous tissues. This process includes detailed analysis to ensure accurate results, potentially offering a new way to enhance cancer surgery precision.