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Trendelenburg Positioning for Anesthesia-Induced Hypotension in Elderly Patients

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What is being tested

Trendelenburg position

+ Supine Horizontal Position

Other
Who is being recruted

From 65 to 90 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Placebo-Controlled
Interventional
Study Start: May 2025
See protocol details

Summary

Principal SponsorZhejiang Cancer Hospital
Study ContactJi Zhu
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 16, 2025

Actual date on which the first participant was enrolled.

The study is exploring a special body position called the Trendelenburg position to see if it helps prevent low blood pressure (hypotension) in older patients undergoing abdominal surgery with general anesthesia. The Trendelenburg position involves tilting the body so that the head is lower than the feet. This research is important because low blood pressure during surgery can lead to complications, and finding simple ways to prevent it could improve safety for elderly patients. During the study, participants are placed either in a 10° Trendelenburg position or lying flat on their back (supine) when anesthesia is administered. Researchers measure the patients' mean arterial pressure, focusing on whether it drops below a certain level, specifically 65 mm Hg, within the first 15 minutes after anesthesia begins. This helps determine if the Trendelenburg position is effective in maintaining stable blood pressure during the early phase of anesthesia.

Official TitleEffect of Trendelenburg Positioning on Anesthesia-Induced Hypotension in Elderly Patients: A Randomized Controlled Clinical Trial
NCT06968091
Principal SponsorZhejiang Cancer Hospital
Study ContactJi Zhu
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

168 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 65 to 90 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

4 inclusion criteria required to participate
patients aged 65-90 years
scheduled for abdominal surgery with general anesthesia
expected to have continuous radial arterial pressure monitoring
American Society of Anesthesiologists (ASA) physical status I to III
6 exclusion criteria prevent from participating
contraindications or failure of radial arterial catheterization
expected possible difficult airway
non-sinus rhythm
increased intracranial pressure
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental

Group II

Placebo

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Zhejiang cancer hospital

Hangzhou, ChinaOpen Zhejiang cancer hospital in Google Maps
Recruiting
One Study Center