Recruiting

Intracoronary Tirofiban for No-Reflow in STEMI Patients

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What is being tested

Intracoronary tirofiban

+ Saline 0.9%

Drug
Who is being recruted

ST Elevation Myocardial Infarction+8

+ Cardiovascular Diseases

+ Heart Diseases

Over 18 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: May 2025
See protocol details

Summary

Principal SponsorKafrelsheikh University
Study ContactMohammed A Hammad, MD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 12, 2025

Actual date on which the first participant was enrolled.

This clinical study focuses on patients experiencing a heart attack known as ST-segment-elevation myocardial infarction (STEMI). This condition often occurs when a plaque in the artery ruptures, obstructing blood flow to the heart. To restore this blood flow, a procedure called primary percutaneous coronary intervention (PCI) is typically used. However, a common issue called the "no-reflow" phenomenon can occur, leading to further complications. This study investigates whether using a drug called intracoronary tirofiban right after opening the blocked artery can help reduce the risk of no-reflow, potentially improving outcomes for patients. Participants in this study undergo the PCI procedure to address the blockage in their coronary artery. After the artery is opened, they receive the drug tirofiban directly into the coronary artery. The study aims to evaluate the effectiveness of this approach by observing if it reduces the occurrence of no-reflow. Although the study does not specify exact benefits or risks, the goal is to determine if this treatment strategy can lead to better recovery and fewer complications following a heart attack.

Official TitleAssessment of No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track
NCT06966674
Principal SponsorKafrelsheikh University
Study ContactMohammed A Hammad, MD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

ST Elevation Myocardial InfarctionCardiovascular DiseasesHeart DiseasesInfarctionIschemiaMyocardial InfarctionNecrosisPathologic ProcessesPathological Conditions, Signs and SymptomsVascular DiseasesMyocardial Ischemia

Criteria

3 inclusion criteria required to participate
Age ≥ 18 years old.

Both sexes.

Patients with STEMI. ST-segment elevated myocardial infarction is defined as typical chest pain >30 minutes with ST-segment elevation of >1 mm in at least 2 consecutive leads on the electrocardiogram or new-onset left bundle brunch block.

7 exclusion criteria prevent from participating
Treatment with thrombolytic drugs in the previous 24 hours.

Known malignancy.

Thrombocytopenia.

End-stage liver disease.

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Patients will receive intracoronary tirofiban (Aggrastat®) (25 mg/kg)

Group II

Placebo
Patients will receive intracoronary saline 0.9% solution as a control group.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Kafrelsheikh University

Kafr ash Shaykh, EgyptOpen Kafrelsheikh University in Google Maps
Recruiting
One Study Center