Completed

CSPR Toothpaste with 8% Arginine for Dentinal Hypersensitivity Relief

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What is being tested

CSPR Toothpaste

+ Colgate Dental Cream Toothpaste

Drug
Who is being recruted

Dentin Sensitivity+2

+ Hypersensitivity

+ Immune System Diseases

From 18 to 70 Years
+18 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 3
Interventional
Study Start: March 2025
See protocol details

Summary

Principal SponsorColgate Palmolive
Last updated: March 20, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 4, 2025

Actual date on which the first participant was enrolled.

This study is designed to test the effectiveness of a new toothpaste, CSPR Toothpaste, which contains 8% arginine. The goal is to find out how well it reduces tooth sensitivity compared to Colgate Cavity Protection Toothpaste. This is particularly important for people who experience sharp pain in their teeth from things like cold air or touch. Understanding which toothpaste works better could help people find faster, more effective relief from this discomfort. Participants in this study will apply the toothpaste directly to their teeth and also use it for regular brushing over an eight-week period. The effectiveness of the toothpaste in reducing sensitivity will be tested at several points: immediately after application, and then again after 3 days, 4 weeks, and 8 weeks. This will help determine not only the immediate but also the long-term benefits of the toothpaste. No specific risks or benefits are mentioned, but the study aims to gather comprehensive data on how both immediate and continued use of the toothpaste affects dental sensitivity.

Official TitleClinical Investigation of the Dentinal Hypersensitivity Reduction Efficacy of CSPR Toothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste Immediately Following Direct Topical Application of the Product and After Subsequent Brushing With the Product for Eight Weeks.
NCT06960148
Principal SponsorColgate Palmolive
Last updated: March 20, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

95 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dentin SensitivityHypersensitivityImmune System DiseasesStomatognathic DiseasesTooth Diseases

Criteria

9 inclusion criteria required to participate
Male and female subjects, ages 18-70, inclusive
Availability for the eight-week duration of the study
Two sensitive teeth, which must be anterior to the molars, and demonstrate cervical erosion/abrasion or gingival recession
Qualifying response to tactile stimuli (Yeaple probe) as defined by a score between 10-50 gms. of force
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9 exclusion criteria prevent from participating
Gross oral pathology, chronic disease, or history of allergy to test products. 2. Advanced periodontal disease or treatment for periodontal disease (including surgery) within the past twelve months
Sensitive teeth with a mobility greater than one
Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures
Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily use of analgesics
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Subjects will be instructed to brush their teeth with their assigned teeth dentifrice and toothbrush twice daily

Group II

Active Comparator
Subjects will be instructed to brush their teeth with their assigned teeth dentifrice and toothbrush twice daily

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

West China Dental Institute of Chengdu

Chengdu, ChinaOpen West China Dental Institute of Chengdu in Google Maps
CompletedOne Study Center