Recruiting

Pumpkin Seed Oil Extract for Overactive Bladder Symptoms

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What is being tested

Pumpkin Seed Extract

Dietary Supplement
Who is being recruted

Urogenital Diseases+8

+ Urinary Bladder Diseases

+ Female Urogenital Diseases and Pregnancy Complications

Over 18 Years
+12 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: April 2025
See protocol details

Summary

Principal SponsorNorthwestern University
Study ContactJulia Geynisman-Tan, MD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 11, 2025

Actual date on which the first participant was enrolled.

This study is exploring the effects of pumpkin seed oil extract on bladder function, particularly for those experiencing overactive bladder (OAB) symptoms like frequent and urgent trips to the bathroom. The research focuses on individuals seeking natural or conservative management methods for their bladder health, especially since traditional treatments often come with unwanted side effects and the exact cause of OAB is not fully understood. By studying the impact of pumpkin seed oil, which has shown promise in other small studies, this research aims to provide more evidence on its effectiveness and safety for a diverse U.S. patient population. Participants in this study will take one pill of pumpkin seed oil extract daily for 12 weeks. Their bladder function will be monitored through questionnaires completed at the start, 4 weeks, and 12 weeks into the study. These surveys will help assess changes in bladder symptoms, pelvic floor control, and willingness to continue using the supplement. The study also looks at whether participants have used other alternative medicines in the past. Participants are advised not to start any new medications or share their supplements during the trial period. The research ensures the confidentiality of participant data, which will be securely stored and later analyzed to understand the potential benefits of pumpkin seed oil extract.

Official TitleEvaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function
NCT06944392
Principal SponsorNorthwestern University
Study ContactJulia Geynisman-Tan, MD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

40 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesUrinary Bladder DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsSigns and SymptomsPathological Conditions, Signs and SymptomsUrologic DiseasesUrological ManifestationsFemale Urogenital DiseasesMale Urogenital DiseasesUrinary Bladder, OveractiveLower Urinary Tract Symptoms

Criteria

1 inclusion criteria required to participate
All patients evaluated at Northwestern's IPHP who report bladder function consistent with overactive bladder (urinary urgency, with or without urinary frequency more than 8 times daily or nocturia, with or without urgency urinary incontinence) at their index visit, who are also willing to use a dietary supplement and not initiate additional behavioral, medication or procedural treatment for 12 weeks following pumpkin seed oil extract initiation.

11 exclusion criteria prevent from participating
Patients with any of the following will be excluded from the study:

Use of other supplements that contain pumpkin seed oil

≥Stage 3 pelvic organ prolapse

Urinary post-void residual ≥150cc

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Upon a patient's enrollment into the study and completion of initial study questionnaires, a research team member will provide the patient with a single bottle of pumpkin seed oil extract. Enrolled patients will be instructed to initiate using the pumpkin seed oil extract starting the day they receive the supplement. Patients will start taking one pill by mouth per day for 12 weeks. They will also be advised to contact their urogynecologist for follow-up if they have not noticed improvement in their bladder health following 3 months of use. Furthermore, they will be counseled about not starting new medications or supplements during their time as a study participant and not sharing their pumpkin seed oil extract with anyone else during their time as a study participant.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Northwestern University

Chicago, United StatesOpen Northwestern University in Google Maps
Recruiting
One Study Center