Recruiting

CPTX2309 Safety and Tolerability in Healthy Volunteers

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What is being tested

CPTX2309

Drug
Who is being recruted

From 18 to 55 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1
Interventional
Study Start: April 2025
See protocol details

Summary

Principal SponsorCapstan Therapeutics
Study ContactClinical Operations
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 9, 2025

Actual date on which the first participant was enrolled.

This clinical trial is focused on testing a new drug called CPTX2309, which is being studied for the first time in humans. The study aims to understand the safety and tolerability of CPTX2309 when given to healthy adults. Researchers are interested in seeing how the body processes the drug and how it affects the body. By doing this, they hope to gather important information that could lead to future treatments for various health conditions. Participants in this study will receive CPTX2309 through an intravenous (IV) line, which means the drug will be administered directly into their bloodstream. The study involves giving different doses to see how safe the drug is and how the body reacts to it. It is an open-label study, meaning both the researchers and participants know what treatment is being given. The main focus is to ensure the drug is safe and to gather data on its effects in the body, which will help guide further research and development.

Official TitleA First-in-Human, Phase 1, Single-Center, Open-Label, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CPTX2309 by Intravenous Administration in Healthy Volunteers
NCT06917742
Principal SponsorCapstan Therapeutics
Study ContactClinical Operations
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

38 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 55 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

Inclusion Criteria: * Male and female participants who are healthy as determined by the investigator based on review of medical history, physical examination, and clinical laboratory tests obtained during the screening period. * Participant is willing and able to adhere to the study visit schedule and other protocol requirements. Exclusion Criteria: * Evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, or clinical laboratory tests beyond what is consistent with a healthy population in the region in which the study is conducted. * Use of any investigational medical device or investigational drug within 30 days or 5 half-lives of the investigational drug (whichever is longer) prior to the first administration of CPTX2309. * Note: Other protocol-defined inclusion/exclusion criteria apply

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Escalating single doses of CPTX2309 on a specified day

Group II

Experimental
Escalating multiple doses of CPTX2309 on specified days

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Nucleus Network Brisbane

Herston, AustraliaOpen Nucleus Network Brisbane in Google Maps
Recruiting
One Study Center
CPTX2309 Safety and Tolerability in Healthy Volunteers | PatLynk