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Sevoflurane vs. Propofol Effects During General Anesthesia

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What is being tested

propofol

+ Sevoflurane

Drug
Who is being recruted

Over 19 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: June 2025
See protocol details

Summary

Principal SponsorPusan National University Yangsan Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 30, 2025

Actual date on which the first participant was enrolled.

This clinical trial aims to compare two drugs, Sevoflurane and Propofol, used during general anesthesia to see how they affect the body's response to pain. It focuses on patients who are undergoing surgeries that require general anesthesia. The study is important because understanding how these drugs impact pain perception can help doctors choose the best anesthetic for minimizing discomfort during surgery. Participants in the study are divided into two groups, with each group receiving either Sevoflurane or Propofol. The researchers use a specific method to simulate a pain event, which involves a brief electrical stimulation. They then record the body's pain response and certain heart and blood pressure measurements before and after this event. This helps determine which drug provides better pain control. There are no specific risks or benefits mentioned in the study description.

Official TitleComparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study
NCT06907823
Principal SponsorPusan National University Yangsan Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 19 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate
American society of anesthesiologists physical status class I or II
8 exclusion criteria prevent from participating
history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.
history of allergic reaction to sevoflurane and/or propofol
history of and/or family history of malignant hyperthermia
neurodegenerative disorder
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Group II

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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