Suspended

KOOS-12 Score in Knee Osteoarthritis Patients

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Arthritis+3

+ Joint Diseases

+ Musculoskeletal Diseases

From 50 to 65 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: March 2025
See protocol details

Summary

Principal SponsorSuperior University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 20, 2025

Actual date on which the first participant was enrolled.

Osteoarthritis (OA) is a common condition that affects the joints, causing significant pain and disability. As the population ages and unhealthy lifestyle habits become more common, the prevalence and impact of OA continue to grow. This study focuses on knee OA and aims to understand the effectiveness of various non-surgical treatments. The main goal is to determine how responsive patients are to these treatments and identify the minimal clinically important difference in the Knee Injury and Osteoarthritis Outcome Score-12 (KOOS-12), a measure used to assess the condition of patients with knee OA. Participants in this study will be asked to complete a questionnaire known as the Global Rating of Change (GRC). This questionnaire will ask them to compare their current condition to their condition at the start of the study, using a scale ranging from -7 (a very great deal worse) to 7 (a very great deal better). Based on their responses, participants will be categorized into either a 'change' group or a 'no change' group. Additionally, the KOOS-12 score will be used to evaluate pain, function, and quality of life. Each item in this score ranges from 0 to 4, with a mean score of 100. A score of 0 indicates severe functional difficulties, while a score of 100 indicates normal function.

Official TitleResponsiveness and Minimal Clinically Important Difference (MCID) of Knee Injury and Osteoarthritis Outcome Score-12 (KOOS-12) in Patients With Knee Osteoarthritis (OA): A Prospective Cohort Study.
NCT06901921
Principal SponsorSuperior University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 50 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

ArthritisJoint DiseasesMusculoskeletal DiseasesOsteoarthritisRheumatic DiseasesOsteoarthritis, Knee

Criteria

5 inclusion criteria required to participate
An Age group of 50-65 years will be included in study.

both males and females will be included.

Patients with Unilateral knee OA with K-L grade II-III involving medial side will be a part of study.

Following ACR (American college of rheumatology) guidelines Patient with knee pain must have 3 or more than 3 of the following symptoms i.e. age >50 years, morning stiffness <30 minutes, crepitus on movement, tenderness, bony enlargements, no palpable warmth will also be a part of study.

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6 exclusion criteria prevent from participating
participants with Traumatic knee injuries (cruciate injuries, meniscal injuries etc.) will be excluded.

Osteonecrosis patients will be excluded.

Patient with Neurological problems won't be a part of this study.

People having Metastasis or neoplasm will be omitted.

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Chaudary Muhammad Akram Teaching Hospital, Azra Naheed Medical College, Superior University

Lahore, PakistanOpen Chaudary Muhammad Akram Teaching Hospital, Azra Naheed Medical College, Superior University in Google Maps
SuspendedOne Study Center