Completed

Optic Nerve Sheath Diameter in Desflurane Anesthesia for Laparoscopic Cholecystectomy

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

From 18 to 65 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: February 2025
See protocol details

Summary

Principal SponsorFatih Sultan Mehmet Training and Research Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2025

Actual date on which the first participant was enrolled.

This study focuses on understanding how different rates of desflurane anesthesia impact the optic nerve sheath diameter during laparoscopic cholecystectomy surgeries. Desflurane is a common anesthetic agent that can mildly increase blood flow and pressure in the brain. While these changes are generally well-tolerated, they need to be closely monitored to prevent complications. The study involves patients aged 18-65 years who are scheduled for elective laparoscopic cholecystectomy under general anesthesia. The research aims to improve the understanding of how anesthesia can be safely administered during such surgeries, potentially enhancing patient care and reducing risks associated with anesthesia. During the study, patients will be divided into two groups based on the fresh gas flow rate used during their anesthesia: 1 L/min or 3 L/min. The optic nerve sheath diameter will be measured using ultrasonography before, during, and after the surgery. These measurements help evaluate changes in intracranial pressure. Patients' heart rate, blood pressure, oxygen levels, and other vital signs will be closely monitored throughout the procedure. The study also records any instances of nausea, vomiting, or shivering in the recovery phase. The results of this study will provide valuable insights into the effects of different anesthesia flow rates on intracranial pressure, potentially guiding future anesthesia practices.

Official TitleComparison of the Effects of Low-Flow and High-Flow Desflurane Anesthesia on Optic Nerve Sheath Diameter in Laparoscopic Cholecystectomy Surgeries
NCT06896604
Principal SponsorFatih Sultan Mehmet Training and Research Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

64 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
Patients Undergoing Elective Laparoscopic Cholecystectomy Under General Anesthesia

Patients aged 18-65 years with an American Society of Anesthesiologists (ASA) physical status classification of I-III and a body mass index (BMI) < 35 kg/m²

Patients who have provided informed consent

6 exclusion criteria prevent from participating
Patients under 18 or over 65 years old, those classified as ASA IV-V, or with a BMI ≥ 35 kg/m²

Patients with conditions that may lead to increased intracranial pressure (e.g., intracranial mass, aneurysm, head trauma), a history of intracranial surgery, previous ischemic or hemorrhagic stroke, or neurological diseases

Patients with a history of glaucoma or cataract surgery

Patients undergoing emergency surgical procedures

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, Turkey (Türkiye)Open Fatih Sultan Mehmet Training and Research Hospital in Google Maps
CompletedOne Study Center