Completed

GKK1-FatigueLactobacillus Plantarum GKK1 for Fatigue Recovery in Active Adults

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What is being tested

Lactobacillus plantarum GKK1 Probiotic

+ Placebo

Dietary Supplement
Who is being recruted

From 18 to 35 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Placebo-Controlled
Interventional
Study Start: September 2024
See protocol details

Summary

Principal SponsorNational Taiwan Sport University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 24, 2024

Actual date on which the first participant was enrolled.

This study explores whether taking a probiotic supplement called Lactobacillus plantarum GKK1 can help reduce tiredness and improve recovery after intense exercise. The supplement, derived from fermented plants, is believed to have beneficial effects on gut health and inflammation, which might aid in managing fatigue. The focus is on healthy adults who regularly engage in physical activities. Understanding if this supplement can help in reducing muscle stress and improving recovery could be beneficial for individuals looking to enhance their exercise performance and recovery. Participants in this study will take the probiotic supplement daily for 28 days while continuing their usual diet and lifestyle but avoiding other supplements. The study uses a controlled exercise routine designed to cause fatigue, such as repetitive jumping movements, to test the supplement's effectiveness. Blood and urine samples will be collected to track changes in stress and muscle damage markers. Both physical tests and personal feedback on fatigue will be used to measure effectiveness. The study aims to see if those taking the probiotic show fewer signs of stress and muscle damage compared to those who do not.

Official TitleEffect of Lactobacillus Plantarum GKK1 Supplementation on Anti-fatigue Health Effects
NCT06893549
Principal SponsorNational Taiwan Sport University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

48 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 35 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

7 inclusion criteria required to participate
Healthy adults aged 18 to 35 years

Non-smokers and non-alcohol drinkers

No history of chronic disease (e.g., cardiovascular disease, diabetes, asthma, metabolic disorders)

No musculoskeletal injuries in the past 6 months

Show More Criteria

6 exclusion criteria prevent from participating
Diagnosed with cardiovascular, metabolic, or neurological disorders

Regular consumption of probiotics within the last three months

Pregnant or lactating women

Individuals taking medication affecting hormonal balance or immune response

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Participants in this group will receive a daily oral supplementation of Lactobacillus plantarum GKK1 probiotic capsules for 28 days. Each capsule contains 50 billion CFU, with a total daily intake of 100 billion CFU. On Day 29, participants will undergo an exhaustive exercise test, and various physiological and biochemical markers will be assessed pre- and post-exercise.

Group II

Placebo
Participants in this group will receive a daily oral supplementation of placebo capsules for 28 days. The placebo capsules contain microcrystalline α-cellulose, magnesium stearate, and silicon dioxide, with identical appearance and taste to the probiotic capsules. On Day 29, participants will undergo an exhaustive exercise test, and various physiological and biochemical markers will be assessed pre- and post-exercise.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

National Taiwan Sport University

Taoyuan, TaiwanOpen National Taiwan Sport University in Google Maps
CompletedOne Study Center