Completed

UthPeak NMNH for Safety and Tolerability in Healthy Adults

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What is being tested

NMNH

+ Placebo

Other
Who is being recruted

From 40 to 65 Years
+25 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Placebo-Controlled
Interventional
Study Start: July 2024
See protocol details

Summary

Principal SponsorEffePharm LTD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 8, 2024

Actual date on which the first participant was enrolled.

This study investigates the safety and how the body processes a compound called UthPeak NMNH, which is a form of nicotinamide mononucleotide. It involves 80 healthy adults who meet specific health criteria. The aim is to understand if different doses of NMNH, taken orally over 90 days, are safe and well-tolerated. This research is important as it could provide insights into how NMNH might support health and well-being by evaluating changes in NAD+ levels, which are linked to energy production and cellular health. Participants are divided into four groups, each receiving either a placebo or different doses of NMNH (125 mg, 250 mg, or 500 mg). They take the supplement daily and have their NAD+ levels, physical abilities, and quality of life assessed at the start, middle, and end of the study. Blood samples are collected at various times after the first dose to measure NAD+ levels, focusing on how the body absorbs and processes the supplement. Regular health checks and monitoring for side effects ensure participant safety.

Official TitleA Prospective, Multi-center, Double-blind, Placebo-controlled, Randomized, Multiple-arm, Parallel Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of UthPeak NMNH (Reduced Nicotinamide Mononucleotide) in Healthy Adult Participants
NCT06889740
Principal SponsorEffePharm LTD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

80 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 40 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

7 inclusion criteria required to participate
Adult healthy male/females aged 40 to 65 years.

Participants with Body Mass Index (BMI) between 18.5 and 35 kg/m2.

Participants who are willing to provide written Informed Consent for participating in the study

Participants who are able to follow verbal and written study directions.

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18 exclusion criteria prevent from participating
Participants on current use of prescription or over-the-counter nicotinic acid.

Participants using any statin drugs.

Participants having used any tobacco product or used a recreational drug in the past 6 months.

Participants having abnormal screening laboratory test values or other lab test result(s) that would preclude study participation in the judgment of the investigator.

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

4 intervention groups are designated in this study

25% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Ingredient: NMNH Dosage form: Capsule, 62.5 mg/capsule Frequency: 2 capsules per day Duration: 90 days

Group II

Experimental
Ingredient: NMNH Dosage form: Capsule, 125 mg/capsule Frequency: 2 capsules per day Duration: 90 days

Group III

Experimental
Ingredient: NMNH Dosage form: Capsule, 250 mg/capsule Frequency: 2 capsules per day Duration: 90 days

Group IV

Placebo
Ingredient: Starch Dosage form: Capsule, 125mg/capsule Frequency: 2 capsules per day Duration: 90 days

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

Medstar Speciality Hospital

Bengaluru, IndiaOpen Medstar Speciality Hospital in Google Maps
Suspended

Vinayaka Mission's Medical College and Hospital

Kāraikāl, India
Completed2 Study Centers