LEAN-PREPLean Mass Preservation with Exercise and Protein in Obesity on Semaglutide/Tirzepatide

This study investigates whether combining resistance exercises and increased protein intake can help preserve lean body mass and enhance physical function in individuals with obesity who are starting weight loss treatments with semaglutide or tirzepatide. These medications are known to promote weight loss, but there is interest in understanding if additional interventions can prevent the loss of muscle mass and improve overall health outcomes. The study is important as it aims to find ways to maintain muscle strength and improve life quality during the weight loss process, addressing challenges faced by people with obesity. Participants in the study will begin their therapy with semaglutide or tirzepatide, initially taking a low dose which will gradually be increased. They will be randomly placed into one of four groups: a control group, a group focusing on increased protein intake, a group engaging in muscle strengthening exercises, or a group doing both exercises and increasing protein intake. The study will run for six months, assessing the impact of these interventions on muscle mass, physical function, as well as potential benefits on blood sugar levels, cholesterol, liver health, quality of life, physical activity, and sleep. This design aims to provide insights into the best strategies for supporting weight loss while maintaining health.