Cortisol Levels in Follicular Fluid Near Ovulation
Data Collection
Collected from today forward - ProspectiveCase-Only
Examining characteristics of individuals with a disease in order to identify genetic or environmental factors contributing to the condition.Summary
Study start date: December 30, 2025
Actual date on which the first participant was enrolled.This study focuses on understanding how the levels of a hormone called cortisol change throughout the day in both blood and follicular fluid. Cortisol is known to have higher levels in the morning and lower levels in the evening. The study is particularly interested in the time around ovulation, a process described as a controlled inflammatory event. It's suggested that cortisol might play a role in limiting tissue damage and aiding repair and remodeling after ovulation, due to its anti-inflammatory properties. In this observational study, researchers collect sets of blood and follicular fluid samples at two different times of the day, 8.00 am and 8.00 pm. The primary goal is to evaluate and compare the concentration of cortisol and cortisone in these samples based on the time of collection. This could help understand if the changes in cortisol levels throughout the day are reflected in the follicular fluid near ovulation.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.20 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Case-only
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Female
Biological sex of participants that are eligible to enroll.From 18 to 35 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Criteria
Inclusion Criteria: * Indication for IVF / ICSI - treatment * Age ≥ 18 years and ≤ 35 years * Body weight: 19 - 29 kg/m2 * Ovarian reserve parameters in the adequate age - range, determined by Anti-Muellerian-Hormone (AMH) and Antral Follicle Count (AFC) (Shebl 2011, Hamdine 2015) * Regular cycle (25-35 days) Exclusion Criteria: * Age \< 18 years and \> 35 years * Body weight \< 60 kg and \> 90 kg * Ovarian reserve parameters outside the adequate age - range, determined by Anti-Muellerian-Hormone (AMH) and Antral Follicle Count (AFC) (Shebl 2011, Hamdine 2015) * Proven poor responder in preceding IVF-treatment-cycle, according to the Bologna criteria: at least two of the following three features must be present: (i) Advanced maternal age (≥40 years) or any other risk factor for POR (poor ovarian response) (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol) (iii) An abnormal ovarian reserve test (i.e. AFC \< 5-7 follicles or AMH \< 0.5 -1.1 ng/ml) * Two episodes of POR after maximal stimulation are sufficient to define a patient as a poor responder in the absence of advanced maternal age or abnormal ORT * Diagnosis of polycystic ovarian syndrome (PCOS), according to Rotterdam criteria * Endometriosis stage 3 or 4 AFS (American Fertility Society) * Irregular cycle (\< 25 days and \> 35 days) * Treatment with GnRH-analogues during the previous 6 months * Intake of contraceptive pill (OCP) or any hormonal treatment during the last 3 months
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
ART Fertility Clinics LLC
Abu Dhabi, United Arab EmiratesOpen ART Fertility Clinics LLC in Google Maps