Completed

Probiotic Yogurt Impact on Gut Health and Microbiota in Healthy Adults

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What is being tested

yogurt intervention

Other
Who is being recruted

From 20 to 65 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Placebo-Controlled
Interventional
Study Start: March 2021
See protocol details

Summary

Principal SponsorTaipei Medical University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 9, 2021

Actual date on which the first participant was enrolled.

The study investigates the effects of a special yogurt containing probiotics on gut health in adults aged 20-65 who are generally healthy and not currently dealing with digestive issues. The goal is to see how this yogurt impacts bowel movements and the types of bacteria in the gut. Participants are asked to avoid other probiotic foods or supplements during the study period, making it easier to attribute any changes to the yogurt being tested. This research is important because understanding how probiotics can benefit gut health could lead to better dietary recommendations for maintaining a healthy digestive system. Participants start with a 2-week adaptation period before being randomly assigned to consume either the probiotic yogurt or a regular dairy product twice daily for 4 weeks. Researchers collect various health measurements, such as body weight and blood markers, at the beginning and end of the study. Participants also keep a food diary and report on their bowel movement patterns. Stool samples are taken to analyze the types of bacteria present, using advanced genetic sequencing techniques. This helps determine how the probiotics in the yogurt might influence gut bacteria composition, which is crucial for understanding its potential health benefits.

Official TitleEffect of Lactobacillus- and Bifidobacterium-containing Yogurt on Gut Microbiota and Short-chained Fatty Acids
NCT06862310
Principal SponsorTaipei Medical University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

22 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 20 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
aged 20-65 years old

without gastrointestinal diseases or other health problems

agree not to consume antibiotics, health supplements that may affect the composition of intestinal flora (ex. probiotics, prebiotics), and fermented dairy products (ex. yogurt, cheese other than those provided in this experiment) during the experiment.

2 exclusion criteria prevent from participating
under pregnancy

with gastrointestinal diseases or other health problems

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Placebo
acidified milk without adding beneficial bacteria

Group II

Experimental
probiotic-enriched fermented milk (2.0 × 10⁹ Colony-forming unit \[CFU\]/mL)

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Taipei Medical University

Taipei, TaiwanOpen Taipei Medical University in Google Maps
CompletedOne Study Center