Recruiting

Norepinephrine vs Phenylephrine for Spinal Anesthesia-Induced Hypotension in Emergency Cesareans

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What is being tested

Norepinephrine Bolus

+ Phenylephrine bolus

Drug
Who is being recruted

From 18 to 40 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: December 2024
See protocol details

Summary

Principal SponsorDow University of Health Sciences
Study ContactRabia Kamal, MBBSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 31, 2024

Actual date on which the first participant was enrolled.

This study investigates how effective two different medications, norepinephrine and phenylephrine, are at preventing low blood pressure caused by spinal anesthesia during emergency cesarean sections. This complication, known as hypotension, is common and can be harmful to both the mother and baby. The study targets pregnant women who need an emergency C-section and are given spinal anesthesia. Understanding which medication better prevents low blood pressure could improve safety and outcomes for mothers and their newborns during surgery. Participants in the study are randomly assigned to receive either norepinephrine or phenylephrine through injections. Researchers monitor important health indicators like heart rate and blood pressure every three minutes. They also assess the newborn's health using the APGAR score right after birth. The study is conducted by healthcare professionals who collect and analyze data to determine the effectiveness of each drug in maintaining stable blood pressure during the procedure. This will help in deciding the best approach to manage anesthesia-induced hypotension in cesarean deliveries.

Official TitleCOMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION- A Double Blind Randomized Controlled Trial
NCT06836986
Principal SponsorDow University of Health Sciences
Study ContactRabia Kamal, MBBSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

124 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 18 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
American society of anesthesiologists II and III patients

Age 18-40years

Gestational age 32 weeks and above

7 exclusion criteria prevent from participating
Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg.

Baseline mean arterial pressure less than 70 mmHg.

Antepartum hemorrhage/intraoperative blood loss greater than 1000ml

history indicative of cardiovascular or neurological disease.

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Prophylactic bolus of norepinephrine will be administered right after spinal anesthesia.

Group II

Active Comparator
Prophylactic bolus of phenylephrine will be administered right after spinal anesthesia induction

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology

Karachi, PakistanOpen Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology in Google Maps
Recruiting
One Study Center
Norepinephrine vs Phenylephrine for Spinal Anesthesia-Induced Hypotension in Emergency Cesareans | PatLynk