MicroEFfAECTAntimicrobial Therapy for Enterococcus Faecalis Bacteremia and Gut Microbiota Signature

This study is focusing on Enterococcus faecalis, a type of bacteria that normally lives in the human gut but can sometimes cause serious infections, including bloodstream infections. These infections are becoming more common, especially in older populations, and they can lead to high mortality rates. Traditional treatment often involves using a single antibiotic, ampicillin, but newer studies suggest that combining different antibiotics might work better in severe cases. The study aims to explore how combinations of antibiotics, like ceftaroline and ceftobiprole with ampicillin or daptomycin, could improve patient outcomes. Additionally, researchers are interested in how these treatments affect the balance of bacteria in the gut, which can be disturbed by antibiotics and lead to further health issues. Participants in the study will receive either a single antibiotic or a combination of antibiotics to treat their infection. Researchers will then track the effectiveness of these treatments by looking at clinical outcomes such as cure rates and any side effects. The study will also use laboratory tests to see how well the antibiotic combinations work together, comparing these results with patient outcomes. By doing this, the study hopes to find the most effective treatment strategy and understand how it affects gut bacteria, potentially leading to better ways to manage these infections and reduce the spread of antibiotic-resistant bacteria.