PPPILPolyphenol Metabotype Characterization in Type 2 Diabetes Patients
This study aims to observe and characterize the overall polyphenol metabotype in your urine, 24 hours after ingesting a polyphenol-rich pill, comparing individuals with type 2 diabetes to healthy age-matched individuals without diabetes.
Data Collection
Collected at a single point in time - Cross-sectionalDiabetes Mellitus+3
+ Diabetes Mellitus, Type 2
+ Endocrine System Diseases
Case-Control
Comparing exposures between individuals with and without disease in order to identify potential risk factors.Summary
Study start date: March 4, 2026
Actual date on which the first participant was enrolled.The study focuses on understanding the overall 'polyphenol metabotype' in people with Type 2 Diabetes Mellitus (T2DM) and comparing it to those without diabetes. Polyphenols are natural compounds found in foods like fruits, vegetables, and tea. The 'metabotype' refers to the unique pattern of these compounds in the body after they have been processed. The study also aims to identify factors, such as gut microbial capacity and transit time, that might influence this metabotype. This research is important as it could provide insights into how dietary polyphenols may impact diabetes management and overall health in individuals with T2DM. Participants in this observational study will consume a pill rich in polyphenols. The study will then analyze the morning urine samples collected 24 hours after consuming the pill. The primary outcome is to find differences in polyphenol metabolites, or breakdown products, in the urine of people with T2DM and healthy individuals. This approach allows the study to characterize the polyphenol metabotype in both groups and compare them.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.100 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Case-Control
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 40 to 85 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 2 locations
Department of rehabilitation sciences - UGent
Ghent, BelgiumOpen Department of rehabilitation sciences - UGent in Google MapsGhent University
Ghent, Belgium