SPESQuantitative Eco-Elastographic Score for Pancreatic Steatosis and Its Correlation with Beta-Cell Function and Metabolic Syndrome

The SPES clinical study is designed to investigate how fat accumulation in the pancreas, known as pancreatic steatosis, affects overall metabolic health. This condition is linked to illnesses like type 2 diabetes and metabolic syndrome, but the precise effects on the pancreas's beta cells, which produce insulin, are not fully understood. The main goal is to create a new ultrasound method that accurately measures pancreatic fat and examines its connection to the functioning of beta cells and the risk of developing diabetes. The study also aims to classify participants into different risk categories for type 2 diabetes, offering potential new insights into personal risk and prevention strategies. In this study, 100 participants between the ages of 18 and 80 will visit the Endoscopic Ultrasound Unit in Rome for non-drug-related procedures. They will undergo an endoscopic ultrasound as part of their routine care, provided they don’t have specific conditions like pancreatic tumors or require insulin treatment. The study involves collecting detailed health information, including body measurements and blood tests, to assess glucose levels and metabolic health. The research will take place over 24 months, potentially improving how individuals are assessed and treated for type 2 diabetes risk and related health issues.