Recruiting

VitC-AgingVitamin C Supplementation for Aging in Middle-Aged and Elderly Adults

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What is being tested

Vitamin C

+ Placebo

Dietary SupplementOther
Who is being recruted

From 18 to 70 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Placebo-Controlled
Interventional
Study Start: April 2025
See protocol details

Summary

Principal SponsorPeking University Third Hospital
Study ContactTian Tian
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 2, 2025

Actual date on which the first participant was enrolled.

This clinical trial is focused on exploring whether taking vitamin C by mouth can help delay signs of aging in middle-aged and elderly adults. The study aims to identify sensitive markers of aging and develop new scientific approaches to slow down the aging process using small molecule drugs like vitamin C. It seeks to determine if vitamin C can positively impact aging-related health indicators and assess the safety of daily vitamin C supplementation. This research could offer valuable insights and guidance for improving health and quality of life as people age. Participants in the study will take two tablets of vitamin C, each containing 250 mg, or a placebo twice a day after breakfast and dinner for a period of 12 months. Regular check-ins are part of the study, with face-to-face meetings every six months and phone calls every two months to monitor progress and distribute the next batch of tablets. Participants are required to report their adherence to the regimen, any side effects, and complete a health questionnaire during these follow-ups. Comprehensive health examinations, including blood tests and other assessments, will be conducted at the six-month and twelve-month marks to evaluate the effects of the supplementation on aging.

Official TitleRandomized Controlled Trial on Vitamin C Supolementation for HealthRegulation in Middle-Aged and Elderly Adults
NCT06794255
Principal SponsorPeking University Third Hospital
Study ContactTian Tian
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

400 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

4 inclusion criteria required to participate
Age: 55-65 years (for the experimental and control groups) or 18-70 years (for the baseline control group assessing aging changes).
Health Status: Deemed to be in good health based on medical evaluation, including medical history, physical examination, laboratory tests, and cardiac monitoring.
Weight: BMI within the range of 18.5-28 kg/m².
Informed Consent: Capable of signing the informed consent form and complying with the requirements and restrictions outlined in the study protocol.
9 exclusion criteria prevent from participating
Disease Status:Uncontrolled medical conditions or any disease that, in the investigator's opinion, may pose an inappropriate risk or contraindication or interfere with the study's objectives, conduct, or evaluation.Severe chronic or acute diseases (e.g., cancer, heart failure, renal insufficiency, COPD, diabetes, active liver disease, metabolic acidosis, poorly controlled hypertension, epilepsy, recent cardiovascular events, inflammatory bowel disease, neurological disorders, infectious diseases, severe autoimmune diseases, etc.).
Weight: BMI < 18.5 or BMI > 28.
Substance/Alcohol Abuse: Ongoing alcohol or drug abuse, or excessive alcohol consumption.
Medical History: History of gastrointestinal diseases, hyperuricemia, kidney or urinary tract stones, glucose-6-phosphate dehydrogenase deficiency, or paroxysmal nocturnal hemoglobinuria.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Participants will take the synthetic vitamin C twice a day, 500mg per time

Group II

Placebo
Participants will take tablets with the same texture, flavor, and appearance as the experimental group twice a day, 500mg per time.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 3 locations

Recruiting

The first affiliated hospital of Nanchang University

Nanchang, ChinaOpen The first affiliated hospital of Nanchang University in Google Maps
Recruiting

People's Hospital of Quzhou

Quzhou, China
Enrolling by invitation

Peking University Third Hospital

Beijing, China
Recruiting
3 Study Centers