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Exercise-Induced Hypoalgesia in Upper and Lower Limb Training

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What is being tested

Lower limb resistance training

+ Upper limb resistance training

Other
Who is being recruted

From 18 to 64 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: February 2025
See protocol details

Summary

Principal SponsorCentro Universitario La Salle
Study ContactÁlvaro Reina-Varona, MSc
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 15, 2025

Actual date on which the first participant was enrolled.

This study focuses on understanding how resistance training can affect pain perception in different parts of the body, specifically comparing exercise involving the arms versus the legs. Healthy participants are divided into three groups: one group performs resistance exercises with their legs, another uses their arms, and a third group does not do any specific exercises for comparison. The goal is to see if exercising specific parts of the body can reduce pain sensitivity, a phenomenon known as exercise-induced hypoalgesia, and to compare the effects between the trained limbs and other areas of the body. This research is important because it could help develop targeted exercise programs to manage pain more effectively. Participants in the study will perform specific resistance exercises such as biceps curls for the arms and leg extensions for the legs. Each exercise session consists of three sets of five repetitions. The study measures the effect of these exercises on pain perception by assessing the pressure pain thresholds in the participants' thighs and elbows. This means researchers will evaluate how much pressure a person can handle before feeling pain at these points, both where they exercised and in another area. By comparing these measurements across the different groups, the study aims to determine how different types of resistance training might influence pain sensitivity in various parts of the body.

Official TitleExercise-Induced Hypoalgesia Differences at Proximal and Distal Regions After Applying a Lower Limb Resistance Training or an Upper Limb Resistance Training Protocol: A Randomized Controlled Trial in Healthy Participants
NCT06765486
Principal SponsorCentro Universitario La Salle
Study ContactÁlvaro Reina-Varona, MSc
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

90 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 64 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate
Asymptomatic subjects aged between 18 and 64 years.

4 exclusion criteria prevent from participating
Pregnant.

Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies.

History of epilepsy.

Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
The participants in the lower limb resistance training group will undergo 3 sets of 5 repetitions of leg extensions with the 5-resistance maximum (5RM), comprising a 5-minute warm-up in cycle ergometer at 1 watt per kg and 60-80 revolutions per minute and 1 set of 5 repetitions with the 10-resistance maximum (10RM).

Group II

Experimental
The participants in the upper limb resistance training group will undergo 3 sets of 5 repetitions of brachial biceps curl with the 5RM, comprising a 5-minute warm-up in cycle ergometer at 1 watt per kg and 60-80 revolutions per minute and 1 set of 5 repetitions with the 10RM.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

CSEU LaSalle

Madrid, SpainOpen CSEU LaSalle in Google Maps
Recruiting
One Study Center