EPICHigh-Velocity Resistance Training in Older Adults With Chronic Kidney Disease
High-Velocity Resistance Training
+ Attention
Urogenital Diseases+9
+ Chronic Disease
+ Female Urogenital Diseases and Pregnancy Complications
Supportive Care Study
Summary
Study start date: July 31, 2025
Actual date on which the first participant was enrolled.This study focuses on improving the physical function of older adults who have advanced chronic kidney disease (CKD). Many of these individuals struggle with daily activities due to weakened muscle function. Researchers believe that enhancing muscle power, which is how quickly and effectively muscles can work, might significantly help. Although exercise programs that focus on building muscle power have shown benefits for older adults, there's limited research on this approach specifically for those with CKD. This study aims to see if a particular type of exercise, called high-velocity resistance training (HVRT), can safely and effectively boost muscle power and physical abilities in this population. Participants in the study will engage in HVRT, a form of exercise that involves performing certain movements as quickly as possible with light weights. The safety and effectiveness of this exercise routine will be closely monitored to see if it helps improve muscle power and overall physical function. No specific risks or benefits are mentioned, but the goal is to determine if this type of exercise could be a viable option for improving the daily lives of older adults with advanced CKD.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.30 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Supportive Care Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 65 to 100 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Chronic kidney disease stages 3-5 * Capacity to complete physical exercise * Lives within 20 miles of Wake Forest Reynolda Campus * Fluent English speaker * Does not plan to travel outside of home area for an extended period of time during study * Willing to be randomized to either intervention group Exclusion Criteria: * Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months * Dependent on a wheelchair * Current participation in a resistance training program * Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months * Absolute contraindications to exercise testing according to ACSM: Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection * Parkinson's disease * Respiratory disease requiring oxygen * Cancer requiring treatment * Currently receiving physical therapy or cardiopulmonary rehabilitation * Type I or insulin dependent Type II Diabetes * Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS) * Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
Active ComparatorStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Wake Forest University Health Sciences
Winston-Salem, United StatesOpen Wake Forest University Health Sciences in Google Maps