Recruiting soon

Angong Niuhuang for Neurologic Dysfunction After Cardiovascular Surgery

What is being tested

Angong Niuhuang Pill (ANP)

+ Control (Standard treatment)

DrugOther

Who is being recruted

Brain Diseases+4

+ Brain Injuries

+ Central Nervous System Diseases

Over 18 Years

+10 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Treatment Study

Interventional

Study Start: January 2025

See protocol details

Summary

Principal SponsorNanjing Medical University

Study ContactHong Liu, MDMore contacts

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2025

Actual date on which the first participant was enrolled.

This study focuses on the potential benefits of a traditional Chinese medicine called Angong Niuhuang Pills (ANPs) for patients who experience moderate-to-severe neurologic problems after undergoing heart surgery. These problems can arise from conditions like atherosclerosis, past strokes, or other artery diseases. The aim is to see if ANPs, known for their anti-inflammatory and heart-protective properties, can help reduce complications such as brain swelling or damage, which are common after such surgeries. This could lead to better recovery outcomes for patients. Participants in the study receive ANPs to assess how safe and effective the treatment is for improving neurologic function after cardiovascular surgery. The study evaluates the effects of the pills on reducing brain-related complications and checks for any side effects. This involves monitoring the participants' health and measuring changes in their neurologic status over time to determine if the treatment helps in their recovery.

Official TitleProtective Effect of Angong Niuhuang Against Negative Inflammatory Response and Neurologic Dysfunction After Cardiovascular Surgery (PANDA X)

NCT06723366

Principal SponsorNanjing Medical University

Study ContactHong Liu, MDMore contacts

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

120 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain DiseasesBrain InjuriesCentral Nervous System DiseasesCraniocerebral TraumaNervous System DiseasesWounds and InjuriesTrauma, Nervous System

Criteria

6 inclusion criteria required to participate

1) an age > 18 years,

2) underwent cardiovascular surgery,

3) diagnosis of acute neurologic dysfunction, including but not limited acute cerebral infarction of the internal carotid artery system,

4) a National Institutes of Health Stroke Scale (NIHSS) score ranging from 10 to 20,

Show More Criteria

4 exclusion criteria prevent from participating

1) not suitable for taking ANP after the dialectical process by a traditional Chinese medical doctor,

2) received ANP within 1 month before stroke onset,

3) liver failure,

4) declined to participate in this study.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Experimental

Group II

standard treatment

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

Beijing Anzhen Hospital, Capital Medical University

Beijing, ChinaOpen Beijing Anzhen Hospital, Capital Medical University in Google Maps

Suspended

The First Affiliated Hospital of Nanjing Medical University

Nanjing, China

Recruiting soon2 Study Centers