ULSBECapsule-sponge Test for Ultralong-segment Barrett's Esophagus

This study is focused on finding a better way to monitor people with a condition called ultralong-segment Barrett's esophagus, which can sometimes lead to a type of cancer called esophageal adenocarcinoma (EAC). Currently, the condition is checked using a procedure called esophagogastroduodenoscopy (EGD), where a doctor looks inside the esophagus with a camera. The study is testing a new method using a device called the Endosign capsule sponge test. This approach might offer a simpler way to check for early signs of cancer, potentially reducing the need for the more invasive EGD procedure. Participants in the study will undergo both the Endosign capsule sponge test and the EGD. The capsule sponge is swallowed and collects cells from the esophagus, which are then analyzed for unusual changes and specific markers, like p53, that could indicate cancer. The study aims to compare the findings from the Endosign test with those from the EGD to see if the new test can reliably detect problems. If successful, this new test could make it easier and less invasive to monitor people with Barrett's esophagus in the future.