Completed

Functional Honey for Sore Throat Relief

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What is being tested

Honey

Dietary Supplement
Who is being recruted

Infections+4

+ Stomatognathic Diseases

+ Otorhinolaryngologic Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: January 2022
See protocol details

Summary

Principal SponsorMedipol University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 6, 2022

Actual date on which the first participant was enrolled.

This study focuses on finding out how different types of honey can help people with sore throats feel better. It involves patients who are already receiving standard treatment for sore throat. The researchers are testing five kinds of honey, each with unique properties like high antioxidant or antimicrobial activities, to see if they can provide additional relief from symptoms. This study is important because it could offer a natural and easily accessible way to relieve sore throat symptoms, which can be common and uncomfortable. During the study, participants are asked to take 15 grams of their assigned type of honey twice a day for ten days. They are observed and checked on the 1st, 3rd, 7th, and 10th days to see how their symptoms change, including sore throat severity, difficulty swallowing, and feelings of fatigue. This process helps researchers understand if and how the honey is helping to reduce these symptoms. The study does not mention any specific risks, but the potential benefit is finding a new way to ease sore throat discomfort.

Official TitleSymptomatic Relief of Sore Throat With Functional Honey: A Randomized Controlled Trial
NCT06715800
Principal SponsorMedipol University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

282 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

InfectionsStomatognathic DiseasesOtorhinolaryngologic DiseasesPharyngeal DiseasesPharyngitisRespiratory Tract DiseasesRespiratory Tract Infections

Criteria

Inclusion Criteria: Adults presenting with sore throat symptoms due to an upper respiratory infection (URI) within the last four days were included in the study. A total of 300 patients over 18 years of age, who were prescribed necessary medication and exhibited signs and symptoms of sore throat, were enrolled. Exclusion Criteria: Exclusion criteria included a history of diabetes, pollen or bee allergies, and aversion to honey. Participants were required not to use any additional products outside of those provided by the researchers during the study period. Written informed consent was obtained from all participants, who were then randomly assigned to either the study or control group.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

6 intervention groups are designated in this study

16.667% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
The group who applied with the complaint of sore throat was cultured and given thyme honey in addition to drug treatment.

Group II

Active Comparator
The group who applied with the complaint of sore throat was cultured and given Yuksekova honey in addition to drug treatment.

Group III

Active Comparator
The group who applied with the complaint of sore throat was cultured and given chestnut honey in addition to drug treatment..

Group IV

Active Comparator
The group who applied with the complaint of sore throat was cultured and given linden honey in addition to drug treatment.

Group 5

Active Comparator
The group who applied with the complaint of sore throat was cultured and given pine honey in addition to drug treatment.

Group 6

Placebo
The group who applied with the complaint of sore throat was cultured and given plasebo in addition to drug treatment.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Istanbul Medipol University

Istanbul, Turkey (Türkiye)Open Istanbul Medipol University in Google Maps
CompletedOne Study Center